Gamma-secretase cleaves NOTCH4

Stable Identifier
R-HSA-9604294
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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NEXT4 fragment of NOTCH4 is further cleaved at the S3 site by the gamma-secretase complex, which releases the intracellular domain NICD4 into the cytosol (Saxena et al. 2001, Das et al. 2004).

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Event Information
Catalyst Activity

aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane]

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