Gamma-secretase cleaves NOTCH4

Stable Identifier
R-HSA-9604294
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Gamma-secretase cleaves NOTCH4
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
NEXT4 fragment of NOTCH4 is further cleaved at the S3 site by the gamma-secretase complex, which releases the intracellular domain NICD4 into the cytosol (Saxena et al. 2001, Das et al. 2004).
Participants
Input
Output
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as an event of
Event Information
Go Biological Process
Notch receptor processing, ligand-dependent (0035333)
Catalyst Activity

aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane]

Physical Entity
gamma-secretase complex [plasma membrane] (Homo sapiens)
Activity
aspartic-type endopeptidase activity (GO:0004190)
Inferred From
Gamma-secretase cleaves Notch4 (Homo sapiens)
Authored
Jassal, B  (2004-12-15)
Orlic-Milacic, M  (2018-04-05)
Reviewed
Joutel, A  (2004-12-15)
Haw, R  (2018-05-01)
Created
Orlic-Milacic, M  (2018-04-02)
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