Gamma-secretase cleaves NOTCH4

Stable Identifier
R-HSA-9604294
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Gamma-secretase cleaves NOTCH4
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NEXT4 fragment of NOTCH4 is further cleaved at the S3 site by the gamma-secretase complex, which releases the intracellular domain NICD4 into the cytosol (Saxena et al. 2001, Das et al. 2004).

Participants
Input
Output
Participant Of
hasEvent
Event Information
Go Biological Process
Notch receptor processing, ligand-dependent (0035333)
Catalyst Activity
Catalyst Activity
Title
aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane]
Physical Entity
gamma-secretase complex [plasma membrane]
Activity
aspartic-type endopeptidase activity (0004190)
Inferred From
Gamma-secretase cleaves Notch4 (Homo sapiens)
Authored
Jassal, B  (2004-12-15)
Orlic-Milacic, M  (2018-04-05)
Reviewed
Joutel, A  (2004-12-15)
Haw, R  (2018-05-01)
Created
Orlic-Milacic, M  (2018-04-02)