Gamma-secretase cleaves NOTCH4

Stable Identifier
R-HSA-9604294
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Gamma-secretase cleaves NOTCH4
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NEXT4 fragment of NOTCH4 is further cleaved at the S3 site by the gamma-secretase complex, which releases the intracellular domain NICD4 into the cytosol (Saxena et al. 2001, Das et al. 2004).

Participants
Input
Output
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as an event of
Event Information
Go Biological Process
Notch receptor processing, ligand-dependent (0035333)
Catalyst Activity

aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane]

Physical Entity
gamma-secretase complex [plasma membrane] (Homo sapiens)
Activity
aspartic-type endopeptidase activity (GO:0004190)
Inferred From
Gamma-secretase cleaves Notch4 (Homo sapiens)
Authored
Jassal, B  (2004-12-15)
Orlic-Milacic, M  (2018-04-05)
Reviewed
Joutel, A  (2004-12-15)
Haw, R  (2018-05-01)
Created
Orlic-Milacic, M  (2018-04-02)
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