Ubiquitinated DVL is degraded by the proteasome

Stable Identifier
R-HSA-1504193
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Ubiquitinated DVL is degraded by the proteasome
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Ubiquitinated Dishevelled is degraded by the proteasome.
Literature References
PubMed ID Title Journal Year
16547521 The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation

Angers, S, Thorpe, CJ, Biechele, TL, Goldenberg, SJ, Zheng, N, Maccoss, MJ, Moon, RT

Nat Cell Biol 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Physical Entity
26S proteasome [cytosol] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Orthologous Events
Ubiquitinated DVL is degraded by the proteasome (Bos taurus)
Ubiquitinated DVL is degraded by the proteasome (Danio rerio)
Ubiquitinated DVL is degraded by the proteasome (Dictyostelium discoideum)
Ubiquitinated DVL is degraded by the proteasome (Gallus gallus)
Ubiquitinated DVL is degraded by the proteasome (Mus musculus)
Ubiquitinated DVL is degraded by the proteasome (Plasmodium falciparum)
Ubiquitinated DVL is degraded by the proteasome (Rattus norvegicus)
Authored
Rothfels, K  (2013-05-30)
Reviewed
Rajakulendran, N  (2014-01-22)
van Amerongen, R  (2014-02-15)
Kikuchi, A  (2014-04-22)
Created
Rothfels, K  (2011-08-24)
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