PTPMT1 dephosphorylates PGP to PG

Stable Identifier
R-HSA-1483197
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial inner membrane, mitochondrial matrix
ReviewStatus
5/5
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PTPMT1 dephosphorylates PGP to PG
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At the inner mitochondrial (IM) membrane, PTPMT1 (phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1) catalyzes the dephosphorylation of phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). The biochemical properties of human PTPMT1 have not been determined; this reaction is inferred from the one catalyzed by the homologous mouse protein (Zhang et al. 2011).
Literature References
PubMed ID Title Journal Year
21641550 Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis

Nguyen, OK, Engel, JL, Perkins, GA, Murphy, AN, Wiley, SE, Zhang, J, Wang, JH, Raetz, CR, Heacock, P, Guan, Z, Dowhan, W, Worby, CA, Dixon, JE

Cell Metab. 2011
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Catalyst Activity

phosphatidylglycerophosphatase activity of PTPMT1 [mitochondrial inner membrane]

Physical Entity
PTPMT1 [mitochondrial inner membrane] (Homo sapiens)
Activity
phosphatidylglycerophosphatase activity (GO:0008962)
Inferred From
Ptpmt1 dephosphorylates PGP to PG (Mus musculus)
Cross References
Rhea
Authored
Williams, MG  (2011-09-14)
Reviewed
Jassal, B  (2013-05-16)
Created
Williams, MG  (2011-08-12)
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