Synthesis of PG

Stable Identifier
R-HSA-1483148
Type
Pathway
Species
Homo sapiens
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Synthesis of PG
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Phosphatidylglycerol (PG) is synthesised at the inner mitochondrial (IM) membrane, phosphatidic acid (PA) and cytidine triphosphate (CTP) are converted into cytidine diphosphate-diacylglycerol (CDP-DAG), which in turn is converted with glycerol-3-phosphate (G3P) into phosphatidylglycerophosphate (PGP) and cytidine monophosphate (CMP). Finally, PGP is dephosphorylated to PG. In addition, PG can be synthesised at the endoplamic reticulum (ER) membrane when phospholipase D transphosphatidylates phosphatidylcholine (PC) with glycerol to displace choline (Cho) and form PG (Piazza & Marmer 2007, Stuhne-Sekalec et al. 1986, Lykidis et al. 1997, Cao & Hatch 1994).

Literature References
Participants
Events
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as an event of
Event Information
Go Biological Process
phosphatidylglycerol biosynthetic process (0006655)
Orthologous Events
Synthesis of PG (Bos taurus)
Synthesis of PG (Caenorhabditis elegans)
Synthesis of PG (Canis familiaris)
Synthesis of PG (Danio rerio)
Synthesis of PG (Dictyostelium discoideum)
Synthesis of PG (Drosophila melanogaster)
Synthesis of PG (Gallus gallus)
Synthesis of PG (Mus musculus)
Synthesis of PG (Plasmodium falciparum)
Synthesis of PG (Rattus norvegicus)
Synthesis of PG (Saccharomyces cerevisiae)
Synthesis of PG (Schizosaccharomyces pombe)
Synthesis of PG (Sus scrofa)
Synthesis of PG (Xenopus tropicalis)
Authored
Williams, MG  (2011-09-14)
Created
Williams, MG  (2011-08-12)
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