MEOS oxidizes ethanol to acetaldehyde

Stable Identifier
R-HSA-143468
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen, endoplasmic reticulum membrane
ReviewStatus
5/5
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MEOS oxidizes ethanol to acetaldehyde
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The MEOS (microsomal ethanol oxidizing system) is an accessory pathway in the liver which increases in activity on chronic alcohol induction. The MEOS utilizes a cytochrome P450 which has since been deciphered to be CYP2E1, an ethanol-inducible form of P450. CYP2E1 also increases acetaldehyde formation and free radicals which can initiate lipid peroxidation. CYP2E1 can also activate many over-the-counter medicines and solvents to toxic metabolites and deplete retinoids resulting in their depletion and deletrious effects. This is because, being a cytochrome P450 and using NADPH and oxygen, it has the ability to biotransform drugs when it has been induced by ethanol.
Literature References
PubMed ID Title Journal Year
8627510 Microsomal ethanol oxidizing system activity by human hepatic cytochrome P450s

Monna, T, Asai, H, Funae, Y, Imaoka, S, Kuroki, T

J Pharmacol Exp Ther 1996
9028626 Ethanol metabolism, cirrhosis and alcoholism

Lieber, CS

Clin Chim Acta 1997
9884161 Respective roles of human cytochrome P-4502E1, 1A2, and 3A4 in the hepatic microsomal ethanol oxidizing system

Tsyrlov, IB, Salmela, KS, Lieber, CS, Kessova, IG

Alcohol Clin Exp Res 1998
Participants
Input
Output
Participates
as an event of
Catalyst Activity

monooxygenase activity of Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane]

Physical Entity
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
Activity
monooxygenase activity (GO:0004497)
Orthologous Events
MEOS oxidizes ethanol to acetaldehyde (Bos taurus)
MEOS oxidizes ethanol to acetaldehyde (Caenorhabditis elegans)
MEOS oxidizes ethanol to acetaldehyde (Canis familiaris)
MEOS oxidizes ethanol to acetaldehyde (Danio rerio)
MEOS oxidizes ethanol to acetaldehyde (Dictyostelium discoideum)
MEOS oxidizes ethanol to acetaldehyde (Drosophila melanogaster)
MEOS oxidizes ethanol to acetaldehyde (Gallus gallus)
MEOS oxidizes ethanol to acetaldehyde (Mus musculus)
MEOS oxidizes ethanol to acetaldehyde (Rattus norvegicus)
MEOS oxidizes ethanol to acetaldehyde (Sus scrofa)
MEOS oxidizes ethanol to acetaldehyde (Xenopus tropicalis)
Authored
Jassal, B  (2008-05-19)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2004-11-10)
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