Reactome | NMT1 [cytosol]

NMT1 [cytosol]

Stable Identifier

R-HSA-60306

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Glycylpeptide N-tetradecanoyltransferase 1 , Peptide N- myristoyltransferase 1, Myristoyl-CoA:protein N-myristoyltransferase 1, Type I N-myristoyltransferase

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - HIV Infection (Homo sapiens)
      - HIV Life Cycle (Homo sapiens)
        
        Late Phase of HIV Life Cycle (Homo sapiens)
        
        Myristoylation of Nef (Homo sapiens)
        
        NMT1 [cytosol] (Homo sapiens)

Sensory Perception (Homo sapiens)

- Visual phototransduction (Homo sapiens)
  - The phototransduction cascade (Homo sapiens)
    - Inactivation, recovery and regulation of the phototransduction cascade (Homo sapiens)
      - NMT1/2 transfer MYS to GNAT1 (Homo sapiens)
        
        NMT1/2 [cytosol] (Homo sapiens)
        
        NMT1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P30419 NMT1

Gene Names

NMT1, NMT

Chain

chain:1-496

Reference Genes

BioGPS Gene:4836 NMT1

COSMIC (genes):NMT1 NMT1

CTD Gene:4836 NMT1

dbSNP Gene:4836 NMT1

ENSEMBL:ENSG00000136448 NMT1

HGNC:7857 NMT1

KEGG:hsa:4836 NMT1

Monarch:4836 NMT1

NCBI Gene:4836 NMT1

OMIM:160993 NMT1

UCSC:P30419 NMT1

Reference Transcript

RefSeq:NM_021079.4 NMT1

Other Identifiers

11722195_s_at

11722196_x_at

11722197_at

11751589_a_at

16834883

201157_PM_s_at

201157_s_at

201158_PM_at

201158_at

201159_PM_s_at

201159_s_at

3723265

3723268

3723269

3723270

3723277

3723278

3723281

3723282

3723283

3723285

3723287

3723288

3723289

3723290

3723291

3723292

3723293

3723294

3723297

3723298

3723299

3723300

3723301

3723302

3723303

3723304

3723305

3723306

3723307

3723312

3723314

38999_s_at

39000_at

4836

8007715

82717_at

A_14_P103416

A_14_P117222

A_23_P107373

A_24_P14010

GE54377

GO:0001701

GO:0003824

GO:0004379

GO:0005515

GO:0005737

GO:0005829

GO:0005886

GO:0006499

GO:0016020

GO:0016740

GO:0016746

GO:0018008

GO:0018030

GO:0019107

GO:0022400

GO:0042180

GO:0048856

GO:0072657

GO:0140096

GO:1903749

HMNXSV003030620

HMNXSV003048730

Hs.111039.0.A1_3p_a_at

ILMN_1762678

M86707_at

PH_hs_0023902

TC17000577.hg

U79285_at

g10835072_3p_a_at

Participates

as a member of

NMT1/2 [cytosol] (Homo sapiens)

Inferred To

nmt1 [cytosol] (Xenopus tropicalis)

nmt1a [cytosol] (Danio rerio)

NMT1 [cytosol] (Bos taurus)

NMT1 [cytosol] (Canis familiaris)

NMT1 [cytosol] (Dictyostelium discoideum)

NMT1 [cytosol] (Gallus gallus)

NMT1 [cytosol] (Mus musculus)

NMT1 [cytosol] (Rattus norvegicus)

NMT1 [cytosol] (Saccharomyces cerevisiae)

NMT1 [cytosol] (Schizosaccharomyces pombe)

NMT1 [cytosol] (Sus scrofa)

Cross References

OpenTargets

ENSG00000136448

ENSEMBL

ENSP00000466827, ENST00000592782, ENSP00000504192, ENST00000258960, ENSP00000258960, ENST00000676828, ENSG00000136448, ENSP00000468424, ENST00000592654, ENST00000678938, ENSP00000503621

HPA

ENSG00000136448-NMT1

GeneCards

NMT1

ZINC - Substances

NMT1_HUMAN

ZINC target

P30419

PRO

P30419

Pharos - Targets

P30419

GlyGen

P30419

ZINC - Predictions - Purchasable

NMT1_HUMAN

HMDB Protein

HMDBP01578

PDB

5UUT, 6QRM, 8Q26, 7RK3, 7OWU, 7OWN, 8Q24, 6PAV, 5O6J, 8Q3T, 8Q3S, 7OWP, 8Q23, 7OWR, 5O6H, 7OWO, 7OWQ, 8Q3D, 4C2Z, 5O9U, 5O9V, 1RXT, 3IWE, 8Q2Z, 6SKJ, 5O9T, 3JTK, 6SJZ, 4C2Y, 5MU6, 3IU2, 5NPQ, 6SK8, 6FZ5, 6SK2, 6SK3, 6F56, 6FZ2, 6FZ3, 3IU1, 5O9S, 6EHJ, 7OWM

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BR61 ACBD6	1	ACBD6 [cytosol] (R-HSA-8848243)	0.765	6
UniProt:P04601 nef	3	nef [cytosol] (R-HIV-165575) myristoylated Nef Protein (UniProt:P04601) [extracellular region] (R-HIV-3597665) myristoylated nef [cytosol] (R-HIV-167605)	0.462	4