TP53 binds the BBC3 (PUMA) promoter

Stable Identifier
R-HSA-4331340
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TP53 binds the BBC3 (PUMA) promoter
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
TP53 (p53) binding sites are found in the promoter (Han et al. 2001) and intron 1 (Nakano and Vousden 2001) of the BBC3 (PUMA) gene, and are necessary for TP53-mediated induction of BBC3 transcription. TP53 family members TP63 (p63) and TP73 (p73) can also bind p53 response elements within the BBC3 gene locus (Bergamaschi et al. 2004, Patel et al. 2008). Formation of the complex between TP53 family members and ASPP proteins PPP1R13B (ASPP1) or TP53BP2 (ASPP2) enhances binding of the p53 family members to the BBC3 gene locus (Bergamaschi et al. 2004, Patel et al. 2008, Wilson et al. 2013).
Literature References
PubMed ID Title Journal Year
23365256 ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo

Feinstein, E, Wilson, AM, Morquette, B, Abdouh, M, Bernier, G, Unsain, N, Di Polo, A, Barker, PA

J. Neurosci. 2013
18676979 Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax

Autore, F, Fraternali, F, Ladbury, JE, Patel, S, George, R, Nikolova, PV

Nucleic Acids Res. 2008
14729977 ASPP1 and ASPP2: common activators of p53 family members

Samuels, Y, Lu, X, Jin, B, Duraisingham, S, Bergamaschi, D, Crook, T

Mol. Cell. Biol. 2004
11572983 Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

Lutz, RJ, Zhu, L, Gu, Z, Flemington, C, Han, J, Chittenden, T, Zambetti, GP, Houghton, AB

Proc. Natl. Acad. Sci. U.S.A. 2001
11463392 PUMA, a novel proapoptotic gene, is induced by p53

Nakano, K, Vousden, KH

Mol Cell 2001
Participants
Input
Output
Participates
as an event of
Authored
Orlic-Milacic, M  (2013-08-15)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2013-08-16)
Cite Us!