Reactome | TP53 binds the BBC3 (PUMA) promoter

TP53 binds the BBC3 (PUMA) promoter

Stable Identifier

R-HSA-4331340

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Homo sapiens)
        
        TP53 binds the BBC3 (PUMA) promoter (Homo sapiens)

General

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TP53 (p53) binding sites are found in the promoter (Han et al. 2001) and intron 1 (Nakano and Vousden 2001) of the BBC3 (PUMA) gene, and are necessary for TP53-mediated induction of BBC3 transcription. TP53 family members TP63 (p63) and TP73 (p73) can also bind p53 response elements within the BBC3 gene locus (Bergamaschi et al. 2004, Patel et al. 2008). Formation of the complex between TP53 family members and ASPP proteins PPP1R13B (ASPP1) or TP53BP2 (ASPP2) enhances binding of the p53 family members to the BBC3 gene locus (Bergamaschi et al. 2004, Patel et al. 2008, Wilson et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23365256	ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo Feinstein, E, Wilson, AM, Morquette, B, Abdouh, M, Bernier, G, Unsain, N, Di Polo, A, Barker, PA	J. Neurosci.	2013
18676979	Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax Autore, F, Fraternali, F, Ladbury, JE, Patel, S, George, R, Nikolova, PV	Nucleic Acids Res.	2008
14729977	ASPP1 and ASPP2: common activators of p53 family members Samuels, Y, Lu, X, Jin, B, Duraisingham, S, Bergamaschi, D, Crook, T	Mol. Cell. Biol.	2004
11572983	Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals Lutz, RJ, Zhu, L, Gu, Z, Flemington, C, Han, J, Chittenden, T, Zambetti, GP, Houghton, AB	Proc. Natl. Acad. Sci. U.S.A.	2001
11463392	PUMA, a novel proapoptotic gene, is induced by p53 Nakano, K, Vousden, KH	Mol Cell	2001

Participants

Input

Output

(p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BBC3 Gene [nucleoplasm] (Homo sapiens)

Participates

as an event of

Authored

Orlic-Milacic, M (2013-08-15)

Reviewed

Zaccara, S (2016-02-04)

Inga, A (2016-02-04)

Created

Orlic-Milacic, M (2013-08-16)