Expression of NAMPT (NamPRT, PBEF, Visfatin)

Stable Identifier
R-HSA-1368889
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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Expression of NAMPT (NamPRT, PBEF, Visfatin)
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The NAMPT (NamPRT) gene is transcribed to yield mRNA and the mRNA is translated to yield protein. As inferred from mouse, the BMAL1:CLOCK (ARNTL:CLOCK) heterodimer enhances transcription of NAMPT. As inferred from mouse, the BMAL1:CLOCK (ARNTL:CLOCK) heterodimer binds an E-box element in the promoter of the NAMPT gene and enhances transcription.
Literature References
PubMed ID Title Journal Year
11241162 Genomic organization of the gene coding for human pre-B-cell colony enhancing factor and expression in human fetal membranes

Garibay-Tupas, J, Yamamoto, SY, Ognjanovic, S, Bao, S, Bryant-Greenwood, GD, Samal, B

J Mol Endocrinol 2001
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-BMAL1:p-CLOCK,NPAS2:NAMPT gene [nucleoplasm] (Homo sapiens)
Inferred From
Expression of Nampt (Mus musculus)
Authored
May, B  (2011-06-30)
Reviewed
Delaunay, F  (2010-06-23)
Kay, SA  (2010-06-23)
Hirota, T  (2010-06-23)
Albrecht, U  (2010-06-23)
Created
May, B  (2011-07-01)
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