TIMM22 inserts proteins into inner membrane

Stable Identifier
R-HSA-1307803
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial intermembrane space, mitochondrial inner membrane
ReviewStatus
5/5
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TIMM22 inserts proteins into inner membrane
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As inferred from the yeast TIM22 complex, human TIMM22 inserts precursor proteins into the inner membrane of the mitochondrion. The precursors are hydrophobic and may be chaperoned to TIMM22 by small TIM proteins (TIMM10, TIMM12) of the intermembrane space. In yeast, experimentally verified substrates of the TIM22 complex include AAC (ADP/ATP translocase 1, ANT, SLC25A4 in human), PIC, TIM22 (TIMM22 in human), and TIM23 (TIMM23 in human). Many other inner membrane proteins are anticipated to be substrates ofthe TIMM22 complex.
Literature References
PubMed ID Title Journal Year
19453276 Multiple pathways for mitochondrial protein traffic

Endo, T, Yamano, K

Biol Chem 2009
18174896 Multiple pathways for sorting mitochondrial precursor proteins

Bolender, N, Sickmann, A, Wagner, R, Meisinger, C, Pfanner, N

EMBO Rep 2008
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Catalyst Activity

membrane insertase activity of TIMM22 [mitochondrial inner membrane]

Physical Entity
TIMM22 [mitochondrial inner membrane] (Homo sapiens)
Activity
membrane insertase activity (GO:0032977)
Inferred From
TIM22 complex inserts proteins into inner membrane (Saccharomyces cerevisiae)
Authored
May, B  (2011-05-23)
Reviewed
D'Eustachio, P  (2011-11-02)
Endo, T  (2012-02-12)
Created
May, B  (2011-05-29)
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