TIM22 complex inserts proteins into inner membrane

Stable Identifier
R-SCE-1252258
Type
Reaction [transition]
Species
Saccharomyces cerevisiae
Compartment
General
SVG |   | PPTX  | SBGN
TIM22 complex inserts proteins into inner membrane

The TIM22 complex inserts precursor proteins into the inner membrane of the mitochondrion (Sirrenberg et al. 1996, Kaldi et al. 1998, Kerscher et al. 1997, Leuenberger et al. 1999, Endres et al. 1999, Kovermann et al. 2002, Rehling et al. 2003, Vergnolle et al. 2005, Yamano et al. 2005). The precursors are hydrophobic and are usually chaperoned to the TIM22 complex by the small TIM proteins (TIM10, TIM12) of the intermembrane space (Koehler et al. 1998, Sirrenberg et al. 1998). Substrates of the TIM22 complex include AAC (Sirrenberg et al. 1996, Kerscher et al. 1997, Leuenberger et al. 1999, Endres et al. 1999, Vergnolle et al. 2005), PIC (Kovermann et al. 2002, Rehling et al. 2003, Yamano et al. 2005), TIM22 (Leuenberger et al. 1999), and TIM23 (Kerscher et al. 1997, Kaldi 1998, Leuenberger et al. 1999).

Literature References
PubMed ID Title Journal Year
11864609 Tim22, the essential core of the mitochondrial protein insertion complex, forms a voltage-activated and signal-gated channel

Kovermann, P, Truscott, KN, Guiard, B, Rehling, P, Sepuri, NB, Müller, H, Jensen, RE, Wagner, R, Pfanner, N

Mol Cell 2002
8955274 Import of carrier proteins into the mitochondrial inner membrane mediated by Tim22

Sirrenberg, C, Bauer, MF, Guiard, B, Neupert, W, Brunner, M

Nature 1996
20457929 Substrate specificity of the TIM22 mitochondrial import pathway revealed with small molecule inhibitor of protein translocation

Hasson, SA, Damoiseaux, R, Glavin, JD, Dabir, DV, Walker, SS, Koehler, CM

Proc Natl Acad Sci U S A 2010
9495346 Carrier protein import into mitochondria mediated by the intermembrane proteins Tim10/Mrs11 and Tim12/Mrs5

Sirrenberg, C, Endres, M, Fölsch, H, Stuart, RA, Neupert, W, Brunner, M

Nature 1998
9430585 Import of mitochondrial carriers mediated by essential proteins of the intermembrane space

Koehler, CM, Jarosch, E, Tokatlidis, K, Schmid, K, Schweyen, RJ, Schatz, G

Science 1998
9501078 Biogenesis of Tim23 and Tim17, integral components of the TIM machinery for matrix-targeted preproteins

Káldi, K, Bauer, MF, Sirrenberg, C, Neupert, W, Brunner, M

EMBO J 1998
12637749 Protein insertion into the mitochondrial inner membrane by a twin-pore translocase

Rehling, P, Model, K, Brandner, K, Kovermann, P, Sickmann, A, Meyer, HE, Kühlbrandt, W, Wagner, R, Truscott, KN, Pfanner, N

Science 2003
10469659 Different import pathways through the mitochondrial intermembrane space for inner membrane proteins

Leuenberger, D, Bally, NA, Schatz, G, Koehler, CM

EMBO J 1999
15320873 A cryptic matrix targeting signal of the yeast ADP/ATP carrier normally inserted by the TIM22 complex is recognized by the TIM23 machinery

Vergnolle, MA, Sawney, H, Junne, T, Dolfini, L, Tokatlidis, K

Biochem J 2005
15644337 The phosphate carrier has an ability to be sorted to either the TIM22 pathway or the TIM23 pathway for its import into yeast mitochondria

Yamano, K, Ishikawa, D, Esaki, M, Endo, T

J Biol Chem 2005
10369662 Transport of the ADP/ATP carrier of mitochondria from the TOM complex to the TIM22.54 complex

Endres, M, Neupert, W, Brunner, M

EMBO J 1999
9412462 The Tim54p-Tim22p complex mediates insertion of proteins into the mitochondrial inner membrane

Kerscher, O, Holder, J, Srinivasan, M, Leung, RS, Jensen, RE

J Cell Biol 1997
Participants
Catalyst Activity

membrane insertase activity of TIM22 Complex [mitochondrial inner membrane]

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