Reactome | TIM22 complex inserts proteins into inner membrane

TIM22 complex inserts proteins into inner membrane

Stable Identifier

R-SCE-1252258

Type

Reaction [transition]

Species

Saccharomyces cerevisiae

Compartment

mitochondrial inner membrane, mitochondrial intermembrane space

ReviewStatus

5/5

General

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TIM22 complex inserts proteins into inner membrane

The TIM22 complex inserts precursor proteins into the inner membrane of the mitochondrion (Sirrenberg et al. 1996, Kaldi et al. 1998, Kerscher et al. 1997, Leuenberger et al. 1999, Endres et al. 1999, Kovermann et al. 2002, Rehling et al. 2003, Vergnolle et al. 2005, Yamano et al. 2005). The precursors are hydrophobic and are usually chaperoned to the TIM22 complex by the small TIM proteins (TIM10, TIM12) of the intermembrane space (Koehler et al. 1998, Sirrenberg et al. 1998). Substrates of the TIM22 complex include AAC (Sirrenberg et al. 1996, Kerscher et al. 1997, Leuenberger et al. 1999, Endres et al. 1999, Vergnolle et al. 2005), PIC (Kovermann et al. 2002, Rehling et al. 2003, Yamano et al. 2005), TIM22 (Leuenberger et al. 1999), and TIM23 (Kerscher et al. 1997, Kaldi 1998, Leuenberger et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
8955274	Import of carrier proteins into the mitochondrial inner membrane mediated by Tim22 Neupert, W, Brunner, M, Guiard, B, Sirrenberg, C, Bauer, MF	Nature	1996
11864609	Tim22, the essential core of the mitochondrial protein insertion complex, forms a voltage-activated and signal-gated channel Pfanner, N, Wagner, R, Kovermann, P, Müller, H, Rehling, P, Jensen, RE, Sepuri, NB, Guiard, B, Truscott, KN	Mol Cell	2002
20457929	Substrate specificity of the TIM22 mitochondrial import pathway revealed with small molecule inhibitor of protein translocation Dabir, DV, Hasson, SA, Walker, SS, Koehler, CM, Glavin, JD, Damoiseaux, R	Proc Natl Acad Sci U S A	2010
9495346	Carrier protein import into mitochondria mediated by the intermembrane proteins Tim10/Mrs11 and Tim12/Mrs5 Neupert, W, Brunner, M, Fölsch, H, Stuart, RA, Endres, M, Sirrenberg, C	Nature	1998
9430585	Import of mitochondrial carriers mediated by essential proteins of the intermembrane space Schatz, G, Tokatlidis, K, Jarosch, E, Koehler, CM, Schmid, K, Schweyen, RJ	Science	1998
9501078	Biogenesis of Tim23 and Tim17, integral components of the TIM machinery for matrix-targeted preproteins Neupert, W, Brunner, M, Káldi, K, Sirrenberg, C, Bauer, MF	EMBO J	1998
12637749	Protein insertion into the mitochondrial inner membrane by a twin-pore translocase Kühlbrandt, W, Pfanner, N, Wagner, R, Kovermann, P, Sickmann, A, Model, K, Rehling, P, Meyer, HE, Truscott, KN, Brandner, K	Science	2003
10469659	Different import pathways through the mitochondrial intermembrane space for inner membrane proteins Schatz, G, Leuenberger, D, Bally, NA, Koehler, CM	EMBO J	1999
15320873	A cryptic matrix targeting signal of the yeast ADP/ATP carrier normally inserted by the TIM22 complex is recognized by the TIM23 machinery Tokatlidis, K, Dolfini, L, Junne, T, Sawney, H, Vergnolle, MA	Biochem J	2005
15644337	The phosphate carrier has an ability to be sorted to either the TIM22 pathway or the TIM23 pathway for its import into yeast mitochondria Esaki, M, Yamano, K, Endo, T, Ishikawa, D	J Biol Chem	2005
10369662	Transport of the ADP/ATP carrier of mitochondria from the TOM complex to the TIM22.54 complex Neupert, W, Brunner, M, Endres, M	EMBO J	1999
9412462	The Tim54p-Tim22p complex mediates insertion of proteins into the mitochondrial inner membrane Holder, J, Leung, RS, Kerscher, O, Jensen, RE, Srinivasan, M	J Cell Biol	1997