Voltage gated Potassium channels

Stable Identifier
R-HSA-1296072
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Voltage gated Potassium channels
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Voltage-gated K+ channels (Kv) determine the excitability of heart, brain and skeletal muscle cells. Kv form octameric channel with alpha subunits that forms the pore of the channel and associated beta subunits. The alpha subunits associate with beta subunits with a stoichiometry of alpha4beta4.The alpha subunits have been classified into 12 families, 1-12 with several representatives from each family. Members of Kv 1-4 form both homotetramers and heterotetramers, however, members of Kv 5-12 form functional heterotetramers. Kv's are expressed in the axon, at axon nodes, somatodendritic sites and axon termini.
Literature References
PubMed ID Title Journal Year
20393197 Ancillary subunits associated with voltage-dependent K+ channels

Pongs, O, Schwarz, JR

Physiol Rev 2010
18446619 Surface expression and distribution of voltage-gated potassium channels in neurons (Review)

Swanton, L, McKeown, L, Jones, OT, Robinson, P

Mol Membr Biol 2008
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Events
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Event Information
Go Biological Process
potassium ion transmembrane transport (0071805)
Orthologous Events
Voltage gated Potassium channels (Bos taurus)
Voltage gated Potassium channels (Canis familiaris)
Voltage gated Potassium channels (Drosophila melanogaster)
Voltage gated Potassium channels (Gallus gallus)
Voltage gated Potassium channels (Mus musculus)
Voltage gated Potassium channels (Rattus norvegicus)
Voltage gated Potassium channels (Sus scrofa)
Voltage gated Potassium channels (Xenopus tropicalis)
Authored
Mahajan, SS  (2011-05-19)
Reviewed
Jassal, B  (2010-09-23)
Created
Mahajan, SS  (2011-05-19)
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