ATP sensitive Potassium channels

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R-HSA-1296025
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Homo sapiens
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ATP sensitive K+ channels couple intracellular metabolism with membrane excitability. These channels are inhibited by ATP so are open in low metabolic states and close in high metabolic states, resulting in membrane depolarization triggering responses such as insulin secretion, modulation of vascular smooth muscle and cardioprotection. The channel comprises four Kir6.x subunits and four regulatory sulphonylurea receptors (SUR) (Akrouh et al, 2009).

Literature References
PubMed ID Title Journal Year
18258787 Human hair follicles contain two forms of ATP-sensitive potassium channels, only one of which is sensitive to minoxidil

Shorter, K, Farjo, NP, Picksley, SM, Randall, VA

FASEB J 2008
19787700 Molecular biology of K(ATP) channels and implications for health and disease

Akrouh, A, Halcomb, SE, Nichols, CG, Sala-Rabanal, M

IUBMB Life 2009
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