Reactome | ATP sensitive Potassium channels

ATP sensitive Potassium channels

Stable Identifier

R-HSA-1296025

Type

Pathway

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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ATP sensitive K+ channels couple intracellular metabolism with membrane excitability. These channels are inhibited by ATP so are open in low metabolic states and close in high metabolic states, resulting in membrane depolarization triggering responses such as insulin secretion, modulation of vascular smooth muscle and cardioprotection. The channel comprises four Kir6.x subunits and four regulatory sulphonylurea receptors (SUR) (Akrouh et al, 2009).

Literature References

PubMed ID	Title	Journal	Year
19787700	Molecular biology of K(ATP) channels and implications for health and disease Halcomb, SE, Akrouh, A, Sala-Rabanal, M, Nichols, CG	IUBMB Life	2009
18258787	Human hair follicles contain two forms of ATP-sensitive potassium channels, only one of which is sensitive to minoxidil Randall, VA, Shorter, K, Picksley, SM, Farjo, NP	FASEB J	2008