Activation of ATP sensitive Potassium channels in muscle cells

Stable Identifier
R-HSA-1369017
Type
Reaction [transition]
Species
Homo sapiens
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In muscle cells such as cardiac, skeletal, vascular and nonvascular smooth muscle, ATP sensitive K+ channels assemble as octamers of four Kir 6.x subunits and four low-affinity sulfonyl urea receptor 2 subunits (SUR2). The human gene encoding SUR2 gives rise to two splice variants, SUR2A and SUR2B. These channels are blocked by excess intracellular levels of ATP. When the ATP is low, ATP dissociates and the channel opens to allow K+ efflux (Krenz et al. 2002).

Literature References
PubMed ID Title Journal Year
12200636 Opening of ATP-sensitive potassium channels causes generation of free radicals in vascular smooth muscle cells

Krenz, M, Oldenburg, O, Wimpee, H, Cohen, MV, Garlid, KD, Critz, SD, Downey, JM, Benoit, JN

Basic Res. Cardiol. 2002
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Participant Of
Catalyst Activity
Catalyst Activity
Title
inward rectifier potassium channel activity of ATP sensitive K+ channels-inwardly rectifying (SUR2) [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
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