Activation of ATP sensitive Potassium channels in muscle cells

Stable Identifier
R-HSA-1369017
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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Activation of ATP sensitive Potassium channels in muscle cells
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In muscle cells such as cardiac, skeletal, vascular and nonvascular smooth muscle, ATP sensitive K+ channels assemble as octamers of four Kir 6.x subunits and four low-affinity sulfonyl urea receptor 2 subunits (SUR2). The human gene encoding SUR2 gives rise to two splice variants, SUR2A and SUR2B. These channels are blocked by excess intracellular levels of ATP. When the ATP is low, ATP dissociates and the channel opens to allow K+ efflux (Krenz et al. 2002).
Literature References
PubMed ID Title Journal Year
12200636 Opening of ATP-sensitive potassium channels causes generation of free radicals in vascular smooth muscle cells

Critz, SD, Krenz, M, Downey, JM, Cohen, MV, Wimpee, H, Oldenburg, O, Garlid, KD, Benoit, JN

Basic Res. Cardiol. 2002
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Input
Output
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as an event of
Catalyst Activity

inward rectifier potassium channel activity of ATP sensitive K+ channels-inwardly rectifying (SUR2) [plasma membrane]

Physical Entity
ATP sensitive K+ channels-inwardly rectifying (SUR2) [plasma membrane] (Homo sapiens)
Activity
inward rectifier potassium channel activity (GO:0005242)
Orthologous Events
Activation of ATP sensitive Potassium channels in muscle cells (Bos taurus)
Activation of ATP sensitive Potassium channels in muscle cells (Canis familiaris)
Activation of ATP sensitive Potassium channels in muscle cells (Drosophila melanogaster)
Activation of ATP sensitive Potassium channels in muscle cells (Gallus gallus)
Activation of ATP sensitive Potassium channels in muscle cells (Mus musculus)
Activation of ATP sensitive Potassium channels in muscle cells (Rattus norvegicus)
Activation of ATP sensitive Potassium channels in muscle cells (Sus scrofa)
Activation of ATP sensitive Potassium channels in muscle cells (Xenopus tropicalis)
Cross References
Rhea
Authored
Mahajan, SS  (2011-05-19)
Reviewed
Jassal, B  (2010-09-23)
Created
Jassal, B  (2011-07-04)
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