Activation of ATP sensitive Potassium channels in neuroendocrine cells

Stable Identifier
R-HSA-1296024
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In neuroendocrine cells such as pancreatic alpha-, beta-, and delta-cells and in the brain, ATP sensitive K+ channels assemble as octamers of four Kir 6.1, 6.2 subunits and four high-affinity sulfonyl urea receptor 1 subunits (SUR1). These channels are blocked by excess intracellular levels of ATP. When the ATP is low, ATP dissociates and the channel opens to allow K+ efflux.

Literature References
PubMed ID Title Journal Year
18258787 Human hair follicles contain two forms of ATP-sensitive potassium channels, only one of which is sensitive to minoxidil

Shorter, K, Farjo, NP, Picksley, SM, Randall, VA

FASEB J 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
potassium channel activity of ATP sensitive K+ channels (SUR1) [plasma membrane]
Physical Entity
Activity
This event is regulated
Negatively by
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
Cite Us!