Activation of ATP sensitive Potassium channels in neuroendocrine cells

Stable Identifier
R-HSA-1296024
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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Activation of ATP sensitive Potassium channels in neuroendocrine cells
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In neuroendocrine cells such as pancreatic alpha-, beta-, and delta-cells and in the brain, ATP sensitive K+ channels assemble as octamers of four Kir 6.1, 6.2 subunits and four high-affinity sulfonyl urea receptor 1 subunits (SUR1). These channels are blocked by excess intracellular levels of ATP. When the ATP is low, ATP dissociates and the channel opens to allow K+ efflux.

Literature References
PubMed ID Title Journal Year
18258787 Human hair follicles contain two forms of ATP-sensitive potassium channels, only one of which is sensitive to minoxidil

Randall, VA, Shorter, K, Picksley, SM, Farjo, NP

FASEB J 2008
Participants
Input
Output
Participates
as an event of
Catalyst Activity

potassium channel activity of ATP sensitive K+ channels (SUR1) [plasma membrane]

Physical Entity
ATP sensitive K+ channels (SUR1) [plasma membrane] (Homo sapiens)
Activity
potassium channel activity (GO:0005267)
This event is regulated
Negatively by
Regulator
ATP [cytosol]
Orthologous Events
Activation of ATP sensitive Potassium channels in neuroendocrine cells (Bos taurus)
Activation of ATP sensitive Potassium channels in neuroendocrine cells (Canis familiaris)
Activation of ATP sensitive Potassium channels in neuroendocrine cells (Danio rerio)
Activation of ATP sensitive Potassium channels in neuroendocrine cells (Drosophila melanogaster)
Activation of ATP sensitive Potassium channels in neuroendocrine cells (Gallus gallus)
Activation of ATP sensitive Potassium channels in neuroendocrine cells (Mus musculus)
Activation of ATP sensitive Potassium channels in neuroendocrine cells (Rattus norvegicus)
Activation of ATP sensitive Potassium channels in neuroendocrine cells (Sus scrofa)
Activation of ATP sensitive Potassium channels in neuroendocrine cells (Xenopus tropicalis)
Cross References
Rhea
Authored
Mahajan, SS  (2011-05-19)
Reviewed
Jassal, B  (2010-09-23)
Created
Mahajan, SS  (2011-05-19)
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