EGFR dimerization

Stable Identifier
R-HSA-177922
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
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EGFR dimerization
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EGF and other growth factors induce oligomerization of their specific receptors. Inactive EGFR monomers are in equilibrium with active EGFR dimers and binding of the EGF ligand stabilizes the active dimeric form.

Literature References
PubMed ID Title Journal Year
8639530 Activation of epidermal growth factor receptor by epidermal growth factor

Kyte, J, Sherrill, JM

Biochemistry 1996
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Input
Output
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as an event of
Orthologous Events
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EGFR dimerization (Rattus norvegicus)
EGFR dimerization (Sus scrofa)
EGFR dimerization (Xenopus tropicalis)
Authored
Castagnoli, L  (2006-10-10)
Reviewed
Muthuswamy, S  (2007-02-17)
Created
Jassal, B  (2006-04-11)
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