EGF and other growth factors induce oligomerization of their specific receptors. Inactive EGFR monomers are in equilibrium with active EGFR dimers and binding of the EGF ligand stabilizes the active dimeric form.

AAMP binding to EGFR, through an unknown mechanism, promotes EGFR dimerization, trans-autophosphorylation and downstream signaling, leading to activation of ERKs (MAPK1 and MAPK3) and expression of cyclin D1 (CCND1) (Yao et al. 2019). Positive regulation of EGFR dimerization by AAMP was shown in the context of EGF-mediated activation of EGFR signaling (Yao et al. 2019). The effect of AAMP in the context of other natural EGFR agonists (TGFA, AREG, EPGN, BTC, EREG, and HBEGF) has not been examined, but is assumed to be qualitatively similar.