Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Nucleosome with H3K4me2 [nucleoplasm]
Stable Identifier
R-HSA-1214200
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic recombination (Homo sapiens)
PRDM9 trimethylates histone H3 (Homo sapiens)
Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Homo sapiens)
Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Homo sapiens)
H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Homo sapiens)
H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Homo sapiens)
H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Homo sapiens)
H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2-Nucleosome [nucleoplasm] (Homo sapiens)
Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2-Nucleosome [nucleoplasm] (Homo sapiens)
Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2-Nucleosome [nucleoplasm] (Homo sapiens)
Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1 gene:H3K4me2-Nucleosome [nucleoplasm] (Homo sapiens)
Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the GP1BA gene (Homo sapiens)
H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the ITGA2B gene (Homo sapiens)
H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the MIR27A gene (Homo sapiens)
H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the THBS1 gene (Homo sapiens)
H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the GP1BA promoter (Homo sapiens)
Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2-Nucleosome [nucleoplasm] (Homo sapiens)
Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the ITGA2B promoter (Homo sapiens)
Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2-Nucleosome [nucleoplasm] (Homo sapiens)
Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the MIR27A gene promoter (Homo sapiens)
Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2-Nucleosome [nucleoplasm] (Homo sapiens)
Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the THBS1 gene promoter (Homo sapiens)
Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1 gene:H3K4me2-Nucleosome [nucleoplasm] (Homo sapiens)
Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
Reproduction (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic recombination (Homo sapiens)
PRDM9 trimethylates histone H3 (Homo sapiens)
Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Estrogen-dependent gene expression (Homo sapiens)
Binding of AP1 transcriptional activator complexes to CCND1 promoter (Homo sapiens)
CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3:ESTG:ESR1 dimer:JUN:ATF2:POUF21:ESTG:ESR1 dimer:JUN:FOS [nucleoplasm] (Homo sapiens)
CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
Estrogen-responsive CCND1 gene expression (Homo sapiens)
CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3:ESTG:ESR1 dimer:JUN:ATF2:POUF21:ESTG:ESR1 dimer:JUN:FOS [nucleoplasm] (Homo sapiens)
CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
FOXA1 and GATA3 bind to CCND1 promoter (Homo sapiens)
CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
CCND1 gene:H3K4me2 nucleosome:YY1:HDAC1 [nucleoplasm] (Homo sapiens)
Nucleosome with H3K4me2 [nucleoplasm] (Homo sapiens)
Participants
components
x 2
HIST1H4 [nucleoplasm]
(Homo sapiens)
x 2
Histone H2A [nucleoplasm]
(Homo sapiens)
x 2
Histone H2B [nucleoplasm]
(Homo sapiens)
x 2
Histone H3 (H3K4me2) [nucleoplasm]
(Homo sapiens)
Participates
as an input of
PRDM9 trimethylates histone H3 (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the ITGA2B gene (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the GP1BA gene (Homo sapiens)
RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the GP1BA promoter (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the THBS1 gene (Homo sapiens)
RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the THBS1 gene promoter (Homo sapiens)
RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the MIR27A gene promoter (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the MIR27A gene (Homo sapiens)
RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the ITGA2B promoter (Homo sapiens)
as a component of
H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2-Nucleosome [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1 gene:H3K4me2-Nucleosome [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2-Nucleosome [nucleoplasm] (Homo sapiens)
H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2-Nucleosome [nucleoplasm] (Homo sapiens)
CCND1 gene:H3K4me2 nucleosome:YY1:HDAC1 [nucleoplasm] (Homo sapiens)
CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
Inferred To
Nucleosome with H3K4me2 [nucleoplasm]
(Bos taurus)
Nucleosome with H3K4me2 [nucleoplasm]
(Caenorhabditis elegans)
Nucleosome with H3K4me2 [nucleoplasm]
(Canis familiaris)
Nucleosome with H3K4me2 [nucleoplasm]
(Danio rerio)
Nucleosome with H3K4me2 [nucleoplasm]
(Dictyostelium discoideum)
Nucleosome with H3K4me2 [nucleoplasm]
(Drosophila melanogaster)
Nucleosome with H3K4me2 [nucleoplasm]
(Gallus gallus)
Nucleosome with H3K4me2 [nucleoplasm]
(Mus musculus)
Nucleosome with H3K4me2 [nucleoplasm]
(Plasmodium falciparum)
Nucleosome with H3K4me2 [nucleoplasm]
(Rattus norvegicus)
Nucleosome with H3K4me2 [nucleoplasm]
(Saccharomyces cerevisiae)
Nucleosome with H3K4me2 [nucleoplasm]
(Schizosaccharomyces pombe)
Nucleosome with H3K4me2 [nucleoplasm]
(Sus scrofa)
Nucleosome with H3K4me2 [nucleoplasm]
(Xenopus tropicalis)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
