PRDM9 trimethylates histone H3

Stable Identifier
R-HSA-1214188
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PRDM9 trimethylates histone H3
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As inferred from experiments in vitro with mouse Prdm9, human PRDM9 methylates histone H3 dimethylated at lysine-4 to yield histone H3 trimethylated at lysine-4.
Literature References
PubMed ID Title Journal Year
16292313 A histone H3 methyltransferase controls epigenetic events required for meiotic prophase

Matsui, Y, Yoshida, K, Hayashi, K

Nature 2005
Participants
Input
Output
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as an event of
Catalyst Activity

histone H3K4 methyltransferase activity of PRDM9:DNA [nucleoplasm]

Physical Entity
PRDM9:DNA [nucleoplasm] (Homo sapiens)
Activity
histone H3K4 methyltransferase activity (GO:0042800)
Inferred From
Prdm9 Trimethylates Histone H3 (murine, bovine) (Bos taurus)
Prdm9 Trimethylates Histone H3 at Lysine-4 (Mus musculus)
Authored
May, B  (2011-02-07)
Reviewed
Bolcun-Filas, E  (2011-02-25)
Lyndaker, A  (2011-02-25)
Holloway, JK  (2011-02-05)
Schimenti, JC  (2011-02-05)
Strong, E  (2011-02-25)
Cohen, PE  (2011-02-05)
Created
May, B  (2011-02-11)
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