Activation of conventional Protein Kinase C

Stable Identifier
Reaction [transition]
Homo sapiens
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The conventional Protein Kinase C (cPKC) isoforms have two membrane-targetting domains, a C1 domain which binds to the membrane lipid diacylglycerol (DAG) and a C2 domain which binds membrane phospholipids such as phosphatidylserine, in a calcium-dependent manner. Association of both domains with the plasma membrane produces a conformational change that releases an autoinhibitory pseudosubstrate segment from the substrate-binding cavity, allowing substrate binding and downstream signaling.

Literature References
PubMed ID Title Journal Year
9814702 Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals

Oancea, E, Meyer, T

Cell 1998
Participant Of
This event is regulated
Positively by
Orthologous Events
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