Activation of conventional Protein Kinase C

Stable Identifier
R-HSA-114553
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Activation of conventional Protein Kinase C
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The conventional Protein Kinase C (cPKC) isoforms have two membrane-targetting domains, a C1 domain which binds to the membrane lipid diacylglycerol (DAG) and a C2 domain which binds membrane phospholipids such as phosphatidylserine, in a calcium-dependent manner. Association of both domains with the plasma membrane produces a conformational change that releases an autoinhibitory pseudosubstrate segment from the substrate-binding cavity, allowing substrate binding and downstream signaling.

Literature References
PubMed ID Title Journal Year
9814702 Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals

Oancea, E, Meyer, T

Cell 1998
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This event is regulated
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Created
de Bono, B  (2004-09-25)
Pace, NP  (2004-09-25)
Farndale, R  (2004-09-25)
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