Activation of conventional Protein Kinase C

Stable Identifier
R-HSA-114553
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The conventional Protein Kinase C (cPKC) isoforms have two membrane-targetting domains, a C1 domain which binds to the membrane lipid diacylglycerol (DAG) and a C2 domain which binds membrane phospholipids such as phosphatidylserine, in a calcium-dependent manner. Association of both domains with the plasma membrane produces a conformational change that releases an autoinhibitory pseudosubstrate segment from the substrate-binding cavity, allowing substrate binding and downstream signaling.

Literature References
PubMed ID Title Journal Year
9814702 Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals

Oancea, E, Meyer, T

Cell 1998
Participants
Participant Of
This event is regulated
Positively by
Orthologous Events
Created
Cite Us!