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SMAC binds XIAP within apoptosome
Stable Identifier
R-HSA-114361
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Apoptotic factor-mediated response (Homo sapiens)
SMAC, XIAP-regulated apoptotic response (Homo sapiens)
SMAC (DIABLO) binds to IAPs (Homo sapiens)
SMAC binds XIAP within apoptosome (Homo sapiens)
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X linked inhibitor of apoptosis protein (XIAP) associates with the active caspase 9 (CASP9) within the APAF1 apoptosome complex. XIAP consists of three baculoviral IAP repeat (BIR) domains and a COOH terminal RING domain (Duckett CS et al. 1996). The BIR3 region of XIAP binds to the amino terminus of the linker peptide on the small subunit of CASP9, which becomes exposed after proteolytic processing of procaspase 9 at Asp315 (Srinivasula SM et al. 2001). SMAC (DIABLO) competes with CASP9 for binding to BIR3 domain of XIAP promoting the release of XIAP from the CASP9:apoptosome complex (Du et al. 2000; Liu Z et al. 2000; Srinivasula SM et al. 2001).
Literature References
PubMed ID
Title
Journal
Year
14960576
Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells.
Du, C
,
Yang, QH
J Biol Chem
2004
11084335
ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas.
Dixit, VM
,
Stennicke, HR
,
Vucic, D
,
Pisabarro, MT
,
Salvesen, GS
Curr Biol
2000
Participants
Input
DIABLO dimer [cytosol]
(Homo sapiens)
XIAP:apoptosome [cytosol]
(Homo sapiens)
Output
APAF1:CYCS:CASP9:XIAP:DIABLO [cytosol]
(Homo sapiens)
Participates
as an event of
SMAC (DIABLO) binds to IAPs (Homo sapiens)
Inferred From
SMAC binds XIAP:Caspase-7 (Homo sapiens)
Reviewed
Matthews, L (2018-11-05)
Created
Alnemri, E (2004-02-17)
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