SMAC binds XIAP within apoptosome

Stable Identifier
R-HSA-114361
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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X linked inhibitor of apoptosis protein (XIAP) associates with the active caspase 9 (CASP9) within the APAF1 apoptosome complex. XIAP consists of three baculoviral IAP repeat (BIR) domains and a COOH terminal RING domain (Duckett CS et al. 1996). The BIR3 region of XIAP binds to the amino terminus of the linker peptide on the small subunit of CASP9, which becomes exposed after proteolytic processing of procaspase 9 at Asp315 (Srinivasula SM et al. 2001). SMAC (DIABLO) competes with CASP9 for binding to BIR3 domain of XIAP promoting the release of XIAP from the CASP9:apoptosome complex (Du et al. 2000; Liu Z et al. 2000; Srinivasula SM et al. 2001).

Literature References
PubMed ID Title Journal Year
11084335 ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas.

Vucic, D, Stennicke, HR, Pisabarro, MT, Salvesen, GS, Dixit, VM

Curr Biol 2000
14960576 Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells.

Yang, QH, Du, C

J Biol Chem 2004
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