Replication initiation regulation by Rb1/E2F1

Stable Identifier
R-HSA-113643
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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This set of events is inferred from annotated events in Drosophila.

Rb1 is normally hyperphosphorylated by CycD/CDK4/CDK6 and Cyclin E/CDK2 for transition into S-phase. PP2A can then reverse this reaction, in this case, in response to DNA damage induced checkpoint.

Participants
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