Reactome | Replication initiation regulation by Rb1/E2F1

Replication initiation regulation by Rb1/E2F1

Stable Identifier

R-HSA-113643

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G1 phase and G1/S transition (Homo sapiens)
    - G1/S Transition (Homo sapiens)
      - E2F mediated regulation of DNA replication (Homo sapiens)
        
        Inhibition of replication initiation of damaged DNA by RB1/E2F1 (Homo sapiens)
        
        Replication initiation regulation by Rb1/E2F1 (Homo sapiens)

General

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Replication initiation regulation by Rb1/E2F1

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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

This set of events is inferred from annotated events in Drosophila.

Rb1 is normally hyperphosphorylated by CycD/CDK4/CDK6 and Cyclin E/CDK2 for transition into S-phase. PP2A can then reverse this reaction, in this case, in response to DNA damage induced checkpoint.

Participants

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