Reactome | Inhibition of replication initiation of damaged DNA by RB1/E2F1

Inhibition of replication initiation of damaged DNA by RB1/E2F1

Stable Identifier

R-HSA-113501

Type

Pathway

Species

Homo sapiens

Compartment

nucleoplasm

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Inhibition of replication initiation of damaged DNA by RB1/E2F1

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During S phase of the cell cycle, RB1 is dephosphorylated by the PP2A protein phosphatase complex. Unphosphorylated RB1 associates with DNA damage sites in S phase, preventing initiation of DNA replication from these sites (Knudsen et al. 2000, Avni et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
17991896	Protein phosphatase 2A subunit PR70 interacts with pRb and mediates its dephosphorylation Magenta, A, Fasanaro, P, Romani, S, Di Stefano, V, Capogrossi, MC, Martelli, F	Mol Cell Biol	2008
14527418	Active localization of the retinoblastoma protein in chromatin and its response to S phase DNA damage. Avni, D, Yang, H, Martelli, F, Hofmann, F, ElShamy, WM, Ganesan, S, Scully, R, Livingston, DM	Mol Cell	2003