During S phase of the cell cycle, RB1 is dephosphorylated by the PP2A protein phosphatase complex. Unphosphorylated RB1 associates with DNA damage sites in S phase, preventing initiation of DNA replication from these sites (Knudsen et al. 2000, Avni et al. 2003).
Magenta, A, Fasanaro, P, Romani, S, Di Stefano, V, Capogrossi, MC, Martelli, F
Avni, D, Yang, H, Martelli, F, Hofmann, F, ElShamy, WM, Ganesan, S, Scully, R, Livingston, DM
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