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Presynaptic depolarization and calcium channel opening
Stable Identifier
R-HSA-112308
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Presynaptic depolarization and calcium channel opening (Homo sapiens)
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Action potentials occur in electrically excitable cells such as neurons, muscles, and endocrine cells. They are initiated by transient opening of voltage dependent sodium channels, causing a rapid, large depolarization of membrane potentials that spread along the axon membrane.
The action potential travels down the axon and reaches the presynaptic terminal depolarizing the membrane in the pre synaptic terminal. The depolarization causes the voltage gated Ca2+ channels to open allowing the influx of Ca2+ that signals the release of neurotransmitter into the synaptic cleft.
Participants
Events
Ca2+ influx through voltage gated Ca2+ channels
(Homo sapiens)
Participates
as an event of
Transmission across Chemical Synapses (Homo sapiens)
Event Information
Go Biological Process
membrane depolarization (0051899)
Orthologous Events
Presynaptic depolarization and calcium channel opening (Bos taurus)
Presynaptic depolarization and calcium channel opening (Caenorhabditis elegans)
Presynaptic depolarization and calcium channel opening (Canis familiaris)
Presynaptic depolarization and calcium channel opening (Drosophila melanogaster)
Presynaptic depolarization and calcium channel opening (Gallus gallus)
Presynaptic depolarization and calcium channel opening (Mus musculus)
Presynaptic depolarization and calcium channel opening (Rattus norvegicus)
Presynaptic depolarization and calcium channel opening (Sus scrofa)
Authored
Mahajan, SS (2008-01-14)
Reviewed
Kavalali, E (2008-04-24)
Wen, H (2020-01-24)
Created
Joshi-Tope, G (2004-04-22)
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