Oxidative dealkylation of 1-etA damaged DNA By ALKBH2

Stable Identifier
R-HSA-112121
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Oxidative dealkylation of 1-etA damaged DNA By ALKBH2
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ALKBH2 catalyzes removal of the ethyl group from 1-ethyladenine (1-etA) in a reaction that depends on oxygen, alpha-ketoglutarate and Fe2+. ALKBH2 thus directly reverses alkylation damage of DNA in the form of 1-etA, releasing acetaldehyde (Duncan et al. 2002).
Literature References
PubMed ID Title Journal Year
12486230 Reversal of DNA alkylation damage by two human dioxygenases.

Duncan, T, Trewick, SC, Koivisto, P, Bates, PA, Lindahl, T, Sedgwick, B

Proc Natl Acad Sci U S A 2002
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Catalyst Activity

dioxygenase activity of ALKBH2:Fe2+:1-etA-dsDNA [nucleoplasm]

Physical Entity
ALKBH2:Fe2+:1-etA-dsDNA [nucleoplasm] (Homo sapiens)
Activity
dioxygenase activity (GO:0051213)
Authored
Pegg, AE  (2004-02-04)
Reviewed
Joshi-Tope, G  (2004-02-04)
Gillespie, ME  (2015-02-06)
Created
Joshi-Tope, G  (2004-04-09)
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