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ALKBH2 mediated reversal of alkylation damage
Stable Identifier
R-HSA-112122
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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DNA Repair (Homo sapiens)
DNA Damage Reversal (Homo sapiens)
Reversal of alkylation damage by DNA dioxygenases (Homo sapiens)
ALKBH2 mediated reversal of alkylation damage (Homo sapiens)
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AlkB is an E.coli alpha-ketoglutarate- and Fe(II)-dependent dioxygenase that oxidizes the relevant methyl groups and releases them as formaldehyde. Two human homologs of AlkB, ALKBH2 and ALKBH3, both remove 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) from methylated polynucleotides in an alpha-ketoglutarate-dependent reaction. They act by direct damage reversal with the regeneration of the unsubstituted bases. E.coli AlkB and human ALKBH2 and ALKBH3 can also repair 1-ethyladenine (1-etA) residues in DNA with the release of acetaldehyde (Duncan et al., 2002, Lee et al. 2005).
Literature References
PubMed ID
Title
Journal
Year
15040447
Repairing DNA-methylation damage.
Sedgwick, B
Nat Rev Mol Cell Biol
2004
16174769
Repair of methylation damage in DNA and RNA by mammalian AlkB homologues
Cai, S
,
Lee, DH
,
O'Connor, TR
,
Jin, SG
,
Pfeifer, GP
,
Chen, Y
J Biol Chem
2005
Participants
Events
ALKBH2 binds alkylated DNA containing 1-meA
(Homo sapiens)
Oxidative demethylation of 1-meA damaged DNA by ALKBH2
(Homo sapiens)
ALKBH2 binds alkylated dsDNA containing 3-meC
(Homo sapiens)
Oxidative demethylation of 3-meC damaged DNA by ALKBH2
(Homo sapiens)
ALKBH2 binds alkylated DNA containing 1-etA
(Homo sapiens)
Oxidative dealkylation of 1-etA damaged DNA By ALKBH2
(Homo sapiens)
Participates
as an event of
Reversal of alkylation damage by DNA dioxygenases (Homo sapiens)
Event Information
Go Biological Process
DNA alkylation repair (0006307)
Authored
Pegg, AE (2004-02-04)
Reviewed
Joshi-Tope, G (2004-02-04)
Gillespie, ME (2015-02-06)
Created
Joshi-Tope, G (2004-04-09)
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