ALKBH2 mediated reversal of alkylation damage

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R-HSA-112122
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Pathway
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Homo sapiens
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AlkB is an E.coli alpha-ketoglutarate- and Fe(II)-dependent dioxygenase that oxidizes the relevant methyl groups and releases them as formaldehyde. Two human homologs of AlkB, ALKBH2 and ALKBH3, both remove 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) from methylated polynucleotides in an alpha-ketoglutarate-dependent reaction. They act by direct damage reversal with the regeneration of the unsubstituted bases. E.coli AlkB and human ALKBH2 and ALKBH3 can also repair 1-ethyladenine (1-etA) residues in DNA with the release of acetaldehyde (Duncan et al., 2002, Lee et al. 2005).

Literature References
PubMed ID Title Journal Year
15040447 Repairing DNA-methylation damage.

Sedgwick, B

Nat Rev Mol Cell Biol 2004
16174769 Repair of methylation damage in DNA and RNA by mammalian AlkB homologues

Cai, S, Lee, DH, O'Connor, TR, Jin, SG, Pfeifer, GP, Chen, Y

J Biol Chem 2005
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