PKC phosphorylates GRK2

Stable Identifier
R-HSA-111970
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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PKC phosphorylates GRK2
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ADRBK1 (also known as GRK2) is phosphorylated at serine 29 in vitro and in vivo by the alpha, gamma and delta isoforms of PKC. PKC-mediated phosphorylation at Ser29 increases ADRBK1 kinase activity towards GPCR substrates, contributing to GPCR desensitization. Phosphorylation at Ser29, which falls within the calmodulin-binding region of ADRBK1, abolishes the inhibitory effect of calmodulin on ADRBK1 kinase activity.

Literature References
PubMed ID Title Journal Year
11042191 Phosphorylation of GRK2 by protein kinase C abolishes its inhibition by calmodulin.

Krasel, C, Dammeier, S, Winstel, R, Brockmann, J, Mischak, H, Lohse, MJ

J Biol Chem 2001
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Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of active PKC (alpha, gamma, delta) [cytosol]
Physical Entity
active PKC (alpha, gamma, delta) [cytosol]
Activity
protein serine/threonine kinase activity (0004674)
Orthologous Events
PKC phosphorylates GRK2 (Bos taurus)
PKC phosphorylates GRK2 (Caenorhabditis elegans)
PKC phosphorylates GRK2 (Canis familiaris)
PKC phosphorylates GRK2 (Danio rerio)
PKC phosphorylates GRK2 (Drosophila melanogaster)
PKC phosphorylates GRK2 (Gallus gallus)
PKC phosphorylates GRK2 (Mus musculus)
PKC phosphorylates GRK2 (Rattus norvegicus)
PKC phosphorylates GRK2 (Sus scrofa)
PKC phosphorylates GRK2 (Xenopus tropicalis)
Authored
Le Novere, N  (2004-03-31)
Jassal, B  (2004-03-31)
Created
Schmidt, EE  (2004-03-26)