ADRBK1 (also known as GRK2) is phosphorylated at serine 29 in vitro and in vivo by the alpha, gamma and delta isoforms of PKC. PKC-mediated phosphorylation at Ser29 increases ADRBK1 kinase activity towards GPCR substrates, contributing to GPCR desensitization. Phosphorylation at Ser29, which falls within the calmodulin-binding region of ADRBK1, abolishes the inhibitory effect of calmodulin on ADRBK1 kinase activity.
Dammeier, S, Winstel, R, Krasel, C, Lohse, MJ, Brockmann, J, Mischak, H
protein serine/threonine kinase activity of active PKC (alpha, gamma, delta) [cytosol]
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