Activation of BIM and translocation to mitochondria

Stable Identifier
R-HSA-111446
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Activation of BIM and translocation to mitochondria
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BIM acts as a sentinel to check the integrity of the cytoskeleton. It exists as two variant proteins: BIM-EL and BIM-L. In healthy cells, these two isoforms are sequestered to the dynein motor complex on microtubules via the dynein light chain DLC1. JNK or MAPK8 releases BIM in response to UV irradiation by phosphorylation.

Literature References
PubMed ID Title Journal Year
14764673 B cell receptor-mediated apoptosis of human lymphocytes is associated with a new regulatory pathway of Bim isoform expression.

Vazquez, A, Leprince, C, Auffredou, MT, Leca, G, Bourgeade, MF, Besnault, L, Mouhamad, S

J Immunol 2004
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway (1900740)
Orthologous Events
Activation of BIM and translocation to mitochondria (Bos taurus)
Activation of BIM and translocation to mitochondria (Canis familiaris)
Activation of BIM and translocation to mitochondria (Gallus gallus)
Activation of BIM and translocation to mitochondria (Mus musculus)
Activation of BIM and translocation to mitochondria (Rattus norvegicus)
Activation of BIM and translocation to mitochondria (Sus scrofa)
Activation of BIM and translocation to mitochondria (Xenopus tropicalis)
Authored
Gopinathrao, G  (2004-08-20)
Reviewed
Vaux, DL  (2023-08-24)
Created
Hardwick, JM  (2004-08-09)
Tsujimoto, Y  (2004-08-09)
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