Reactome | Formation of Pol zeta complex

Formation of Pol zeta complex

Stable Identifier

R-HSA-110322

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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REV3L (hREV3), the catalytic subunit of DNA polymerase zeta (POLZ) belonging to B family of DNA polymerases, binds the adapter protein MAD2L2 (hREV7) to form a functional POLZ complex (Murakamo et al. 2000, Murakamo et al. 2001, Hara et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
11485998	Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7 Murakumo, Y, Ogura, Y, Ishii, H, Numata, S, Ichihara, M, Croce, CM, Fishel, R, Takahashi, M	J. Biol. Chem.	2001
10660610	A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2 Murakumo, Y, Roth, T, Ishii, H, Rasio, D, Numata, S, Croce, CM, Fishel, R	J. Biol. Chem.	2000
20164194	Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV1 Hara, K, Hashimoto, H, Murakumo, Y, Kobayashi, S, Kogame, T, Unzai, S, Akashi, S, Takeda, S, Shimizu, T, Sato, M	J. Biol. Chem.	2010