Reactome | REV1 inserts dCMP opposite to AP sites in DNA

REV1 inserts dCMP opposite to AP sites in DNA

Stable Identifier

R-HSA-110308

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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REV1 inserts dCMP opposite to AP sites in DNA

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REV1 acts as a deoxycytidyl transferase to incorporate a single dCMP opposite a damaged DNA residue. REV1 most efficiently incorporates dCMP opposite apurinic/apyrimidinic (AP, abasic) sites. REV1 enables DNA damage bypass without repair of damaged DNA bases, but its low fidelity results in a mutagenic effect (Nelson et al. 1996, Lin et al. 1999, Gibbs et al. 2000, Zhang et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
8751446	Deoxycytidyl transferase activity of yeast REV1 protein Nelson, JR, Lawrence, CW, Hinkle, DC	Nature	1996
11917024	Response of human REV1 to different DNA damage: preferential dCMP insertion opposite the lesion Zhang, Y, Wu, X, Rechkoblit, O, Geacintov, NE, Taylor, JS, Wang, Z	Nucleic Acids Res.	2002
10536157	The human REV1 gene codes for a DNA template-dependent dCMP transferase. Lin, W, Xin, H, Zhang, Y, Wu, X, Yuan, F	Nucleic Acids Res	1999
10760286	The function of the human homolog of Saccharomyces cerevisiae REV1 is required for mutagenesis induced by UV light. Gibbs, PE, Wang, XD, Li, Z, McManus, TP, McGregor, WG, Lawrence, CW, Maher, VM	Proc Natl Acad Sci U S A	2000