REV1 acts as a deoxycytidyl transferase to incorporate a single dCMP opposite a damaged DNA residue. REV1 most efficiently incorporates dCMP opposite apurinic/apyrimidinic (AP, abasic) sites. REV1 enables DNA damage bypass without repair of damaged DNA bases, but its low fidelity results in a mutagenic effect (Nelson et al. 1996, Lin et al. 1999, Gibbs et al. 2000, Zhang et al. 2002).
Nelson, JR, Hinkle, DC, Lawrence, CW
Taylor, JS, Rechkoblit, O, Zhang, Y, Wang, Z, Geacintov, NE, Wu, X
Zhang, Y, Yuan, F, Lin, W, Xin, H, Wu, X
Maher, VM, McGregor, WG, Lawrence, CW, Li, Z, McManus, TP, Gibbs, PE, Wang, XD
deoxycytidyl transferase activity of REV1:MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template [nucleoplasm]
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