REV1 acts as a deoxycytidyl transferase to incorporate a single dCMP opposite a damaged DNA residue. REV1 most efficiently incorporates dCMP opposite apurinic/apyrimidinic (AP, abasic) sites. REV1 enables DNA damage bypass without repair of damaged DNA bases, but its low fidelity results in a mutagenic effect (Nelson et al. 1996, Lin et al. 1999, Gibbs et al. 2000, Zhang et al. 2002).
Zhang, Y, Wu, X, Rechkoblit, O, Geacintov, NE, Taylor, JS, Wang, Z
Nelson, JR, Lawrence, CW, Hinkle, DC
Lin, W, Xin, H, Zhang, Y, Wu, X, Yuan, F
Gibbs, PE, Wang, XD, Li, Z, McManus, TP, McGregor, WG, Lawrence, CW, Maher, VM
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