Cleavage of ethenoadenine by MPG glycosylase

Stable Identifier
R-HSA-110250
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Cleavage of ethenoadenine by MPG glycosylase
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
MPG, a 3-methyladenine DNA glycosylase, cleaves the alkylated DNA base 1,N6-ethenoadenine (Dosanjh et al. 1994, Saparbaev et al. 1995).
Literature References
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as an event of
Catalyst Activity

DNA N-glycosylase activity of MPG:EtAD-dsDNA [nucleoplasm]

Physical Entity
MPG:EtAD-dsDNA [nucleoplasm] (Homo sapiens)
Activity
DNA N-glycosylase activity (GO:0019104)
Orthologous Events
Cleavage of ethenoadenine by MPG glycosylase (Bos taurus)
Cleavage of ethenoadenine by MPG glycosylase (Canis familiaris)
Cleavage of ethenoadenine by MPG glycosylase (Danio rerio)
Cleavage of ethenoadenine by MPG glycosylase (Gallus gallus)
Cleavage of ethenoadenine by MPG glycosylase (Mus musculus)
Cleavage of ethenoadenine by MPG glycosylase (Plasmodium falciparum)
Cleavage of ethenoadenine by MPG glycosylase (Rattus norvegicus)
Cleavage of ethenoadenine by MPG glycosylase (Sus scrofa)
Cleavage of ethenoadenine by MPG glycosylase (Xenopus tropicalis)
Authored
Matthews, L  (2004-02-03)
Reviewed
Borowiec, JA  (2014-12-22)
Created
Matthews, L  (2004-01-29)
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