Reactome | MPG glycosylase mediated recognition and binding of ethenoadenine

MPG glycosylase mediated recognition and binding of ethenoadenine

Stable Identifier

R-HSA-110239

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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MPG glycosylase mediated recognition and binding of ethenoadenine

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MPG, a 3-methyladenine DNA glycosylase, recognizes alkylation damage of DNA in the form of 1,N6-ethenoadenine (Dosanjh et al. 1994, Saparbaev et al. 1995).

Literature References

PubMed ID	Title	Journal	Year
8110764	1,N6-ethenoadenine is preferred over 3-methyladenine as substrate by a cloned human N-methylpurine-DNA glycosylase (3-methyladenine-DNA glycosylase) Roy, R, Dosanjh, MK, Singer, B, Mitra, S	Biochemistry	1994
7479006	Escherichia coli, Saccharomyces cerevisiae, rat and human 3-methyladenine DNA glycosylases repair 1,N6-ethenoadenine when present in DNA Laval, J, Kleibl, K, Saparbaev, M	Nucleic Acids Res.	1995

Participants

Input

Output

MPG:EtAD-dsDNA [nucleoplasm] (Homo sapiens)

Participates

as an event of

Recognition and association of DNA glycosylase with site containing an affected purine (Homo sapiens)

Authored

Matthews, L (2004-02-03)

Reviewed

Borowiec, JA (2014-12-22)

Created

Matthews, L (2004-01-29)

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