MUTYH (MYH), an A/G-specific adenine DNA glycosylase, was cloned as the human homolog of E.coli DNA repair gene mutY (Slupska et al. 1996). MUTYH recognizes adenines and 2-hydroxyadenines on the newly synthesized DNA strand mispaired with guanines or 8-oxoguanines on the template strand (Ohtsubo et al. 2000, Boldogh et al. 2001).