MUTYH mediated recognition and binding of an adenine opposite to an 8-oxoguanine

Stable Identifier
R-HSA-110237
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

MUTYH (MYH), an A/G-specific adenine DNA glycosylase, was cloned as the human homolog of E.coli DNA repair gene mutY (Slupska et al. 1996). MUTYH recognizes adenines and 2-hydroxyadenines on the newly synthesized DNA strand mispaired with guanines or 8-oxoguanines on the template strand (Ohtsubo et al. 2000, Boldogh et al. 2001).

Literature References
PubMed ID Title Journal Year
11433026 hMYH cell cycle-dependent expression, subcellular localization and association with replication foci: evidence suggesting replication-coupled repair of adenine:8-oxoguanine mispairs

Boldogh, I, Milligan, D, Lee, MS, Bassett, H, Lloyd, RS, McCullough, AK

Nucleic Acids Res. 2001
8682794 Cloning and sequencing a human homolog (hMYH) of the Escherichia coli mutY gene whose function is required for the repair of oxidative DNA damage

Slupska, MM, Baikalov, C, Luther, WM, Chiang, JH, Wei, YF, Miller, JH

J. Bacteriol. 1996
10684930 Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria

Ohtsubo, T, Nishioka, K, Imaiso, Y, Iwai, S, Shimokawa, H, Oda, H, Fujiwara, T, Nakabeppu, Y

Nucleic Acids Res. 2000
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