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IL6R [plasma membrane]
Stable Identifier
R-HSA-197824
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
IL6RA, Interleukin-6 receptor alpha chain, IL6RA_HUMAN, CD126
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Transcriptional regulation of granulopoiesis (Homo sapiens)
IL6R gene expression is enhanced by CEBPA (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
Potential therapeutics for SARS (Homo sapiens)
IL6R binds IL6R inhibitors (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
IL6R:IL6R inhibitors [plasma membrane] (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of STAT3-upregulated plasma membrane proteins (Homo sapiens)
STAT3-upregulated plasma membrane proteins [plasma membrane] (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
Interleukin-6 family signaling (Homo sapiens)
Interleukin-6 signaling (Homo sapiens)
Assembly of hexameric IL-6 receptor (Homo sapiens)
IL6 receptor hexamer:JAKs [plasma membrane] (Homo sapiens)
IL6 receptor trimer:JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:IL6RB:JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
IL6 receptor trimer:JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:IL6RB:JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
IL6 binds IL6R (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
IL6R:IL6R inhibitors [plasma membrane] (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
IL6:IL6RA:IL6RB:JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
IL6R binds IL6R inhibitors (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
IL6R:IL6R inhibitors [plasma membrane] (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
IL6ST is tyrosine phosphorylated (Homo sapiens)
IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6 receptor trimer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
JAK activation (Homo sapiens)
IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6 receptor trimer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
IL6 receptor hexamer:JAKs [plasma membrane] (Homo sapiens)
IL6 receptor trimer:JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:IL6RB:JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
PTPN11 binds CBL (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11:CBL [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
PTPN11 binds p-Y759-IL6ST (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
PTPN11 is phosphorylated (Homo sapiens)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
Phosphorylated STATs are released (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
SOCS3 binds IL6ST (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
Serine phosphorylation of STATs (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine/serine phosphorylated STAT1/3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6ST binds STAT1,STAT3 (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:SOCS3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs:Tyrosine phosphorylated STAT1,STAT3 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF-independent MAPK1/3 activation (Homo sapiens)
MAPK1 (ERK2) activation (Homo sapiens)
MAP2K2 binds MAPK1 (Homo sapiens)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
MAPK3 (ERK1) activation (Homo sapiens)
MAP2K1 binds MAPK3 (Homo sapiens)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Homo sapiens)
Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6RA:Tyrosine phosphorylated IL6RB:Activated JAKs [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08887 IL6R
Gene Names
IL6R
Chain
signal peptide:1-19, chain:20-468, chain:20-355
Reference Genes
COSMIC (genes):IL6R IL6R
dbSNP Gene:3570 IL6R
ENSEMBL:ENSG00000160712 IL6R
Participates
as a member of
STAT3-upregulated plasma membrane proteins [plasma membrane] (Homo sapiens)
as an output of
IL6R gene expression is enhanced by CEBPA (Homo sapiens)
as an input of
IL6R binds IL6R inhibitors (Homo sapiens)
IL6 binds IL6R (Homo sapiens)
as a component of
IL6R:IL6R inhibitors [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
Inferred To
cntfr [plasma membrane]
(Danio rerio)
IL6R [plasma membrane]
(Bos taurus)
IL6R [plasma membrane]
(Canis familiaris)
IL6R [plasma membrane]
(Gallus gallus)
Il6ra [plasma membrane]
(Mus musculus)
Ghost homologue of IL6R [plasma membrane]
(Sus scrofa)
Ghost homologue of IL6R [plasma membrane]
(Xenopus tropicalis)
Il6r [plasma membrane]
(Rattus norvegicus)
let-805 [plasma membrane]
(Caenorhabditis elegans)
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05231 IL6
3
IL6 [extracellular region]
(R-HSA-447100)
IL6 [endoplasmic reticulum lumen]
(R-HSA-8956764)
p-IL6 [endoplasmic reticulum lumen]
(R-HSA-8957044)
0.823
7
UniProt:Q92673 SORL1
2
SORL1 [endosome membrane]
(R-HSA-8871475)
SORL1 [Golgi membrane]
(R-HSA-8871510)
0.619
7
UniProt:Q2HRC7 VIL6
0.591
3
UniProt:Q96EQ0 SGTB
0.556
3
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