Reactome | GBP1 [cytosol]

GBP1 [cytosol]

Stable Identifier

R-HSA-1031698

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Interferon-induced guanylate-binding protein 1, GBP1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P03372 ESR1

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Influenza Infection (Homo sapiens)
      - NS1 Mediated Effects on Host Pathways (Homo sapiens)
        
        NS1 binds GBP1 (Homo sapiens)
        
        GBP1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P32455 GBP1

Gene Names

GBP1

Chain

chain:1-589, propeptide:590-592

Reference Genes

BioGPS Gene:2633 GBP1

COSMIC - genes:GBP1 GBP1

CTD Gene:2633 GBP1

dbSNP Gene:2633 GBP1

ENSEMBL:ENSG00000117228 GBP1

HGNC:4182 GBP1

KEGG:hsa:2633 GBP1

Monarch:2633 GBP1

NCBI Gene:2633 GBP1

OMIM:600411 GBP1

UCSC:P32455 GBP1

Reference Transcript

RefSeq:NM_002053.3 GBP1

Other Identifiers

11726328_x_at

11726329_x_at

11749773_x_at

11752930_a_at

11752931_x_at

16689332

202269_PM_x_at

202269_x_at

202270_PM_at

202270_at

231577_3p_s_at

231577_PM_s_at

231577_s_at

2345791

2345792

2345796

2345851

2345852

2345856

2345857

2345860

2345862

2345863

2345864

2421851

2421862

2421863

2421870

2421882

2421884

2421885

2421886

2421890

2421891

2421892

2421893

2421894

2421895

2421897

2421899

2421900

2421901

2421902

2421903

2421904

2421905

2421906

2421907

2421908

2421909

2421910

2421911

2421912

2421914

2421941

2421951

2633

35735_at

73236_g_at

7917516

A_23_P62890

GE81108

GE85507

GO:0000139

GO:0000166

GO:0001530

GO:0002376

GO:0003779

GO:0003924

GO:0003925

GO:0004382

GO:0005515

GO:0005525

GO:0005576

GO:0005737

GO:0005794

GO:0005829

GO:0005856

GO:0005886

GO:0008092

GO:0008289

GO:0012506

GO:0015629

GO:0016020

GO:0016787

GO:0019003

GO:0019899

GO:0019955

GO:0030507

GO:0030659

GO:0031410

GO:0032703

GO:0042742

GO:0042802

GO:0042803

GO:0042832

GO:0045087

GO:0050848

GO:0050860

GO:0051604

GO:0051607

GO:0051715

GO:0051879

GO:0065003

GO:0070373

GO:0071346

GO:0071347

GO:0071356

GO:0072665

GO:0098542

GO:0098772

GO:0106139

GO:0140639

GO:0160075

GO:1900025

GO:1903076

GO:1903077

HMNXSV003027931

Hs.62661.1.A1_3p_a_at

ILMN_1701114

ILMN_2148785

M55542_at

PH_hs_0040710

TC01002847.hg

g12803662_3p_a_at

Participates

as a member of

as an input of

as a component of

GBP1:NS1 [cytosol] (Homo sapiens)

Other forms of this molecule

S-farn-C589-GBP1 [cytosol]

S-farn-C589, p-S156, T590-GBP1 [cytosol]

GBP1(1-192) [cytosol]

GBP1(193-592) [cytosol]

K48polyUb-GBP1 [cytosol]

Inferred To

gbp2 [cytosol] (Danio rerio)

Gbp1 [cytosol] (Rattus norvegicus)

gbp6.2 [cytosol] (Xenopus tropicalis)

gbp4 [cytosol] (Xenopus tropicalis)

Gbp3 [cytosol] (Rattus norvegicus)

LOC121106469 [cytosol] (Gallus gallus)

gbp7 [cytosol] (Xenopus tropicalis)

LOC121106627 [cytosol] (Gallus gallus)

LOC121106626 [cytosol] (Gallus gallus)

GBP1 [cytosol] (Bos taurus)

GBP1 [cytosol] (Canis familiaris)

GBP1 [cytosol] (Danio rerio)

GBP1 [cytosol] (Dictyostelium discoideum)

GBP1 [cytosol] (Gallus gallus)

GBP1 [cytosol] (Sus scrofa)

gbp1 [cytosol] (Danio rerio)

gbp1 [cytosol] (Xenopus tropicalis)

Homologues of GBP1 [cytosol] (Bos taurus)

Homologues of GBP1 [cytosol] (Danio rerio)

Homologues of GBP1 [cytosol] (Gallus gallus)

Homologues of GBP1 [cytosol] (Rattus norvegicus)

Homologues of GBP1 [cytosol] (Xenopus tropicalis)

si:ch211-209n20.1 [cytosol] (Danio rerio)

Cross References

RefSeq

NP_002044.2

OpenTargets

ENSG00000117228

ENSEMBL

ENSG00000117228, ENST00000370473, ENSP00000359504

HPA

ENSG00000117228-GBP1

GeneCards

GBP1

PRO

P32455

Pharos - Targets

P32455

HMDB Protein

HMDBP08414

PDB

1DG3, 2B8W, 1F5N, 2B92, 8Q4L, 6K2D, 8R1A, 8CQB, 6LOJ, 2D4H, 6K1Z, 2BC9

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P32455 GBP1	6	GBP1 [cytosol] (R-HSA-1031698) S-farn-C589-GBP1 [cytosol] (R-HSA-9947912) S-farn-C589, p-S156, T590-GBP1 [cytosol] (R-HSA-9954274) GBP1(1-192) [cytosol] (R-HSA-9956711) GBP1(193-592) [cytosol] (R-HSA-9956716) K48polyUb-GBP1 [cytosol] (R-HSA-9955186)	0.862	15
UniProt:Q9H0R5 GBP3	1	GBP3 [cytosol] (R-HSA-1031696)	0.788	6
UniProt:P32456 GBP2	3	K48polyUb-GBP2 [cytosol] (R-HSA-9955197) GGC-C588-GBP2 [cytosol] (R-HSA-9947851) GBP2 [cytosol] (R-HSA-1015673)	0.716	11
UniProt:Q96PP8 GBP5	2	GGC-C583-GBP5 [cytosol] (R-HSA-9954196) GBP5 [cytosol] (R-HSA-1031692)	0.716	11
UniProt:Q9NYH9 UTP6	1	UTP6 [nucleoplasm] (R-HSA-6790674)	0.564	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-ESR1 [cytosol] (R-HSA-9632177) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.527	2
UniProt:Q96EP0 RNF31	1	RNF31 [cytosol] (R-HSA-5212660)	0.527	2
UniProt:P43652 AFAM			0.527	2
UniProt:Q96PP9 GBP4	2	K48polyUb-GBP4 [cytosol] (R-HSA-9955155) GBP4 [cytosol] (R-HSA-1031691)	0.508	2

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