Reactome | GBP4 [cytosol]

GBP4 [cytosol]

Stable Identifier

R-HSA-1031691

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Guanylate-binding protein 4, GBP4_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Bacterial Infection Pathways (Homo sapiens)
    - Infection with Enterobacteria (Homo sapiens)
      - Enterobacterial factors antagonize host defense (Homo sapiens)
        
        CASP4 binds CALM:OspC3 (Homo sapiens)
        
        CALM:OspC3:CASP4:LPS, CALM:OspC3:CASP4:LPS:GBPs [cytosol] (Homo sapiens)
        
        CALM:OspC3:CASP4:LPS:GBPs [cytosol] (Homo sapiens)
        
        2xCASP4:LPS:(GBP1:GBP2:GBP3:GBP4:GDP) oligomer [cytosol] (Homo sapiens)
        
        LPS:(GBP1:GBP2:GBP3:GBP4) oligomer [cytosol] (Homo sapiens)
        
        LPS:GBP1 oligomer:GBP2:GBP3:GBP4:GDP [cytosol] (Homo sapiens)
        
        GBP4 [cytosol] (Homo sapiens)
        
        CASP4:LPS, CASP4:LPS:GBPs [cytosol] (Homo sapiens)
        
        2xCASP4:LPS:(GBP1:GBP2:GBP3:GBP4:GDP) oligomer [cytosol] (Homo sapiens)
        
        LPS:(GBP1:GBP2:GBP3:GBP4) oligomer [cytosol] (Homo sapiens)
        
        LPS:GBP1 oligomer:GBP2:GBP3:GBP4:GDP [cytosol] (Homo sapiens)
        
        GBP4 [cytosol] (Homo sapiens)
        
        OspC3 ADP-riboxanates CASP4 (Homo sapiens)
        
        ADPrbx-R314-CASP4:LPS, ADPrbx-R314-CASP4:LPS:GBPs [cytosol] (Homo sapiens)
        
        2xADPrbx-R314-CASP4:LPS:GBPs [cytosol] (Homo sapiens)
        
        LPS:(GBP1:GBP2:GBP3:GBP4) oligomer [cytosol] (Homo sapiens)
        
        LPS:GBP1 oligomer:GBP2:GBP3:GBP4:GDP [cytosol] (Homo sapiens)
        
        GBP4 [cytosol] (Homo sapiens)
        
        CALM:OspC3:CASP4:LPS, CALM:OspC3:CASP4:LPS:GBPs [cytosol] (Homo sapiens)
        
        CALM:OspC3:CASP4:LPS:GBPs [cytosol] (Homo sapiens)
        
        2xCASP4:LPS:(GBP1:GBP2:GBP3:GBP4:GDP) oligomer [cytosol] (Homo sapiens)
        
        LPS:(GBP1:GBP2:GBP3:GBP4) oligomer [cytosol] (Homo sapiens)
        
        LPS:GBP1 oligomer:GBP2:GBP3:GBP4:GDP [cytosol] (Homo sapiens)
        
        GBP4 [cytosol] (Homo sapiens)
        
        S.flexneri ipaH9.8 binds GBPs (Homo sapiens)
        
        GBP1,GBP2,GBP4,GBP6 [cytosol] (Homo sapiens)
        
        GBP4 [cytosol] (Homo sapiens)
        
        ipaH9.8:Ub:UBE2D2:GBPs [cytosol] (Homo sapiens)
        
        GBP1,GBP2,GBP4,GBP6 [cytosol] (Homo sapiens)
        
        GBP4 [cytosol] (Homo sapiens)
        
        S.flexneri ipaH9.8 ubiquitinates GBPs (Homo sapiens)
        
        ipaH9.8:Ub:UBE2D2:GBPs [cytosol] (Homo sapiens)
        
        GBP1,GBP2,GBP4,GBP6 [cytosol] (Homo sapiens)
        
        GBP4 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96PP9 GBP4

Gene Names

GBP4

Chain

chain:1-640

Reference Genes

BioGPS Gene:115361 GBP4

COSMIC (genes):GBP4 GBP4

CTD Gene:115361 GBP4

dbSNP Gene:115361 GBP4

ENSEMBL:ENSG00000162654 GBP4

HGNC:20480 GBP4

KEGG:hsa:115361 GBP4

Monarch:115361 GBP4

NCBI Gene:115361 GBP4

OMIM:612466 GBP4

UCSC:Q96PP9 GBP4

Reference Transcript

RefSeq:NM_052941.4 GBP4

Other Identifiers

115361

11733950_at

11733951_at

11733952_at

11733953_x_at

11749595_a_at

16689384

2345820

235175_PM_at

235175_at

235574_PM_at

235574_at

2421978

2421979

2421996

2421997

2421998

2421999

2422000

2422001

2422002

2422003

2422006

2422007

2422008

2422009

2422011

2422014

2422015

2422018

2422019

2422020

2422021

2422023

2422024

2422026

2422028

2422029

2422030

70458_i_at

70460_f_at

7917561

84909_at

A_23_P103496

A_24_P45446

GO:0000139

GO:0000166

GO:0002376

GO:0003924

GO:0005515

GO:0005525

GO:0005634

GO:0005737

GO:0005794

GO:0005829

GO:0005886

GO:0016020

GO:0016787

GO:0031410

GO:0042802

GO:0042803

GO:0042832

GO:0045087

GO:0048471

GO:0050830

GO:0071346

GO:0098542

HMNXSV003021476

Hs.138360.0.A1_3p_at

Hs.240849.0.A1_3p_at

ILMN_1771385

PH_hs_0024812

TC01002849.hg

Participates

as a member of

GBP1,GBP2,GBP4,GBP6 [cytosol] (Homo sapiens)

as an input of

GBP2, GBP3, GBP4 bind to GBP1 oligomer on the bacterial surface (Homo sapiens)

as a component of

as a candidate of

GBP [cytosol] (Homo sapiens)

Other forms of this molecule

K48polyUb-GBP4 [cytosol]

Inferred To

Homologues of GBP4 [cytosol] (Danio rerio)

Homologues of GBP4 [cytosol] (Gallus gallus)

Homologues of GBP4 [cytosol] (Xenopus tropicalis)

gbp2 [cytosol] (Danio rerio)

LOC507055 [cytosol] (Bos taurus)

gbp4 [cytosol] (Danio rerio)

gbp4 [cytosol] (Xenopus tropicalis)

LOC121106469 [cytosol] (Gallus gallus)

gbp7 [cytosol] (Xenopus tropicalis)

LOC100495160 [cytosol] (Xenopus tropicalis)

LOC121106627 [cytosol] (Gallus gallus)

LOC121106626 [cytosol] (Gallus gallus)

GBP1 [cytosol] (Gallus gallus)

GBP4 [cytosol] (Dictyostelium discoideum)

GBP4 [cytosol] (Gallus gallus)

Ghost homologue of GBP4 [cytosol] (Rattus norvegicus)

gbp1 [cytosol] (Danio rerio)

gbp1 [cytosol] (Xenopus tropicalis)

LOC100155195 [cytosol] (Sus scrofa)

si:ch211-209n20.1 [cytosol] (Danio rerio)

Cross References

RefSeq

NP_443173.2

ENSEMBL

ENSG00000162654, ENST00000355754, ENSP00000359490

OpenTargets

ENSG00000162654

GeneCards

GBP4

HPA

ENSG00000162654-GBP4

PRO

Q96PP9

Pharos - Targets

Q96PP9

HMDB Protein

HMDBP08417

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96PP8 GBP5	2	GGC-C583-GBP5 [cytosol] (R-HSA-9954196) GBP5 [cytosol] (R-HSA-1031692)	0.508	2
UniProt:Q96PP9 GBP4	2	K48polyUb-GBP4 [cytosol] (R-HSA-9955155) GBP4 [cytosol] (R-HSA-1031691)	0.508	2
UniProt:P32456 GBP2	3	K48polyUb-GBP2 [cytosol] (R-HSA-9955197) GGC-C588-GBP2 [cytosol] (R-HSA-9947851) GBP2 [cytosol] (R-HSA-1015673)	0.508	2
UniProt:P32455 GBP1	6	GBP1 [cytosol] (R-HSA-1031698) S-farn-C589-GBP1 [cytosol] (R-HSA-9947912) S-farn-C589, p-S156, T590-GBP1 [cytosol] (R-HSA-9954274) GBP1(1-192) [cytosol] (R-HSA-9956711) GBP1(193-592) [cytosol] (R-HSA-9956716) K48polyUb-GBP1 [cytosol] (R-HSA-9955186)	0.508	2