FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP

Stable Identifier
R-HSA-1028788
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Addition of alpha 1,6 fucose to the first GlcNAc of the N-glycan
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Addition of a fucose moiety as an alpha 1-6 linkage to the first GlcNAc residue of the N-glycan (Clarke JL, Watkins WM 1999; Yamaguchi Y et al, 1999; Yamaguchi Y et al 2000).

Literature References
PubMed ID Title Journal Year
10814706 Genomic structure and promoter analysis of the human alpha1, 6-fucosyltransferase gene (FUT8)

Yamaguchi, Y, Ikeda, Y, Takahashi, T, Ihara, H, Tanaka, T, Sasho, C, Uozumi, N, Yanagidani, S, Inoue, S, Fujii, J, Taniguchi, N

Glycobiology 2000
10343104 Mapping of the alpha-1,6-fucosyltransferase gene, FUT8, to human chromosome 14q24.3

Yamaguchi, Y, Fujii, J, Inoue, S, Uozumi, N, Yanagidani, S, Ikeda, Y, Egashira, M, Miyoshi, O, Niikawa, N, Taniguchi, N

Cytogenet Cell Genet 1999
9949196 Expression of human alpha-l-fucosyltransferase gene homologs in monkey kidney COS cells and modification of potential fucosyltransferase acceptor substrates by an endogenous glycosidase

Clarke, JL, Watkins, WM

Glycobiology 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glycoprotein 6-alpha-L-fucosyltransferase activity of FUT8 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created