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Reactions specific to the complex N-glycan synthesis pathway
Stable Identifier
R-HSA-975578
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
N-glycan antennae elongation in the medial/trans-Golgi (Homo sapiens)
Reactions specific to the complex N-glycan synthesis pathway (Homo sapiens)
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If MAN2 acts before MGAT3, the pathway progresses to complex N-glycans, because MAN2 is not able to operate on bisected oligosaccharides (11421343, page 5). The expression of MAN2 over MGAT3 in a tissue can regulate the synthesis of hybrid or complex N-glycans.
Participants
Events
Trimming of mannoses on the alpha1,6 arm by MAN2A1
(Homo sapiens)
Addition of a GlcNAc on the alpha 1,4 branch by MGAT2
(Homo sapiens)
FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP
(Homo sapiens)
FUT3 transfers L-fucose to Gal1,3GlcNAc
(Homo sapiens)
FUCA1 hydrolyses NGP:1,6-GlcNAc
(Homo sapiens)
CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin
(Homo sapiens)
CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1
(Homo sapiens)
Participates
as an event of
N-glycan antennae elongation in the medial/trans-Golgi (Homo sapiens)
Orthologous Events
Reactions specific to the complex N-glycan synthesis pathway (Bos taurus)
Reactions specific to the complex N-glycan synthesis pathway (Caenorhabditis elegans)
Reactions specific to the complex N-glycan synthesis pathway (Canis familiaris)
Reactions specific to the complex N-glycan synthesis pathway (Danio rerio)
Reactions specific to the complex N-glycan synthesis pathway (Dictyostelium discoideum)
Reactions specific to the complex N-glycan synthesis pathway (Drosophila melanogaster)
Reactions specific to the complex N-glycan synthesis pathway (Gallus gallus)
Reactions specific to the complex N-glycan synthesis pathway (Mus musculus)
Reactions specific to the complex N-glycan synthesis pathway (Rattus norvegicus)
Reactions specific to the complex N-glycan synthesis pathway (Sus scrofa)
Reactions specific to the complex N-glycan synthesis pathway (Xenopus tropicalis)
Authored
Dall'Olio, GM (2009-11-10)
Reviewed
Gagneux, P (2010-11-18)
Created
Jassal, B (2010-09-30)
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