Reactome | IRF1 [cytosol]

IRF1 [cytosol]

Stable Identifier

R-HSA-1015686

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Interferon regulatory factor 1, IRF1_HUMAN

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P10914 IRF1

Gene Names

IRF1

Chain

chain:1-325

Reference Genes

BioGPS Gene:3659 IRF1

COSMIC (genes):IRF1 IRF1

CTD Gene:3659 IRF1

dbSNP Gene:3659 IRF1

ENSEMBL:ENSG00000125347 IRF1

ENSEMBL_homo_sapiens_GENE:ENSG00000125347.15 IRF1

HGNC:6116 IRF1

KEGG Gene (Homo sapiens):3659 IRF1

Monarch:3659 IRF1

NCBI Gene:3659 IRF1

OMIM:147575 IRF1

Reference Transcript

RefSeq:NM_002198.2 IRF1

Other Identifiers

11716733_at

11716734_at

11754035_a_at

16999776

202531_PM_at

202531_at

238725_PM_at

238725_at

2875347

2875349

2875350

2875351

2875353

2875356

2875358

2875360

2875362

2875363

2875364

2875365

2875366

2875372

2875374

2875375

3659

59777_at

669_s_at

8114010

A_23_P41765

GE59715

GE819413

GO:0000785

GO:0000976

GO:0000977

GO:0000978

GO:0000981

GO:0001228

GO:0002376

GO:0002819

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0006915

GO:0007155

GO:0008285

GO:0010468

GO:0012501

GO:0023052

GO:0030154

GO:0032481

GO:0032728

GO:0032735

GO:0034124

GO:0035458

GO:0043226

GO:0043374

GO:0043565

GO:0045087

GO:0045088

GO:0045590

GO:0045892

GO:0045893

GO:0045944

GO:0048856

GO:0051607

GO:0051726

GO:0060333

GO:0071260

GO:0098542

GO:0140110

GO:2000564

HMNXSV003052729

Hs.180559.0.A1_3p_at

ILMN_1708375

L05072_s_at

PH_hs_0004638

PH_hs_0010683

g4504720_3p_at

Participates

as a member of

IRF 1-9 [cytosol] (Homo sapiens)

Other forms of this molecule

IRF1 [nucleoplasm]

Cross References

RefSeq

NP_002189.1

OpenTargets

ENSG00000125347

GeneCards

P10914

HPA

ENSG00000125347-IRF1

Ensembl

ENST00000405885, ENST00000245414, ENSP00000384406, ENSG00000125347, ENSP00000245414

PRO

P10914

Pharos - Targets

P10914

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) SUMO1 [nucleoplasm] (R-HSA-877304) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562)	0.544	2
UniProt:Q14653 IRF3	6	p-5S,T404-IRF3 [nucleoplasm] (R-HSA-936418) p-4S,T404-IRF3 [nucleoplasm] (R-HSA-177654) p-4S,T404-IRF3 [cytosol] (R-HSA-166258) IRF3(272-427) [cytosol] (R-HSA-9729737) IRF3(2-271) [cytosol] (R-HSA-9729696) IRF3 [cytosol] (R-HSA-166251)	0.537	5
UniProt:P03129 VE7			0.527	4
UniProt:Q16236 NFE2L2	13	p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-NFE2L2 [cytosol] (R-HSA-9758077) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109)	0.508	3

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