Reactome | CASP8 [cytosol]

CASP8 [cytosol]

Stable Identifier

R-GGA-76158

Type

Protein [EntityWithAccessionedSequence]

Species

Gallus gallus

Compartment

cytosol

Synonyms

CASP8(385-479), A0A8V0ZVJ3

Locations in the PathwayBrowser

Expand all

Immune System (Gallus gallus)

- Cytokine Signaling in Immune system (Gallus gallus)
  - Signaling by Interleukins (Gallus gallus)
    - Interleukin-1 family signaling (Gallus gallus)
      - Interleukin-1 signaling (Gallus gallus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Gallus gallus)
        
        Regulation of NF-kappa B signaling (Gallus gallus)
        
        CASP8 cleaves N4BP1 at D424, D490 (Gallus gallus)
        
        active caspase-8 [cytosol] (Gallus gallus)
        
        Caspase-8 dimer [cytosol] (Gallus gallus)
        
        CASP8 [cytosol] (Gallus gallus)
        
        N4BP1 binds IKBKG (Gallus gallus)
        
        active caspase-8 [cytosol] (Gallus gallus)
        
        Caspase-8 dimer [cytosol] (Gallus gallus)
        
        CASP8 [cytosol] (Gallus gallus)
- Innate Immune System (Gallus gallus)
  - C-type lectin receptors (CLRs) (Gallus gallus)
    - CLEC7A (Dectin-1) signaling (Gallus gallus)
      - CLEC7A/inflammasome pathway (Gallus gallus)
        
        Caspase-8 binds MALT (Gallus gallus)
        
        MALT1:active caspase-8 [cytosol] (Gallus gallus)
        
        active caspase-8 [cytosol] (Gallus gallus)
        
        Caspase-8 dimer [cytosol] (Gallus gallus)
        
        CASP8 [cytosol] (Gallus gallus)
        
        active caspase-8 [cytosol] (Gallus gallus)
        
        Caspase-8 dimer [cytosol] (Gallus gallus)
        
        CASP8 [cytosol] (Gallus gallus)
  - Toll-like Receptor Cascades (Gallus gallus)
    - Toll Like Receptor 10 (TLR10) Cascade (Gallus gallus)
      - MyD88 cascade initiated on plasma membrane (Gallus gallus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Gallus gallus)
        
        Regulation of NF-kappa B signaling (Gallus gallus)
        
        CASP8 cleaves N4BP1 at D424, D490 (Gallus gallus)
        
        active caspase-8 [cytosol] (Gallus gallus)
        
        Caspase-8 dimer [cytosol] (Gallus gallus)
        
        CASP8 [cytosol] (Gallus gallus)
        
        N4BP1 binds IKBKG (Gallus gallus)
        
        active caspase-8 [cytosol] (Gallus gallus)
        
        Caspase-8 dimer [cytosol] (Gallus gallus)
        
        CASP8 [cytosol] (Gallus gallus)
    - Toll Like Receptor 2 (TLR2) Cascade (Gallus gallus)
      - Toll Like Receptor TLR1:TLR2 Cascade (Gallus gallus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Gallus gallus)
        
        Regulation of NF-kappa B signaling (Gallus gallus)
        
        CASP8 cleaves N4BP1 at D424, D490 (Gallus gallus)
        
        active caspase-8 [cytosol] (Gallus gallus)
        
        Caspase-8 dimer [cytosol] (Gallus gallus)
        
        CASP8 [cytosol] (Gallus gallus)
        
        N4BP1 binds IKBKG (Gallus gallus)
        
        active caspase-8 [cytosol] (Gallus gallus)
        
        Caspase-8 dimer [cytosol] (Gallus gallus)
        
        CASP8 [cytosol] (Gallus gallus)
      - Toll Like Receptor TLR6:TLR2 Cascade (Gallus gallus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Gallus gallus)
        
        Regulation of NF-kappa B signaling (Gallus gallus)
        
        CASP8 cleaves N4BP1 at D424, D490 (Gallus gallus)
        
        active caspase-8 [cytosol] (Gallus gallus)
        
        Caspase-8 dimer [cytosol] (Gallus gallus)
        
        CASP8 [cytosol] (Gallus gallus)
        
        N4BP1 binds IKBKG (Gallus gallus)
        
        active caspase-8 [cytosol] (Gallus gallus)
        
        Caspase-8 dimer [cytosol] (Gallus gallus)
        
        CASP8 [cytosol] (Gallus gallus)
    - Toll Like Receptor 3 (TLR3) Cascade (Gallus gallus)
      - TAK1-dependent IKK and NF-kappa-B activation (Gallus gallus)
        
        Regulation of NF-kappa B signaling (Gallus gallus)
        
        CASP8 cleaves N4BP1 at D424, D490 (Gallus gallus)
        
        active caspase-8 [cytosol] (Gallus gallus)
        
        Caspase-8 dimer [cytosol] (Gallus gallus)
        
        CASP8 [cytosol] (Gallus gallus)
        
        N4BP1 binds IKBKG (Gallus gallus)
        
        active caspase-8 [cytosol] (Gallus gallus)
        
        Caspase-8 dimer [cytosol] (Gallus gallus)
        
        CASP8 [cytosol] (Gallus gallus)
    - Toll Like Receptor 4 (TLR4) Cascade (Gallus gallus)
      - MyD88-independent TLR4 cascade (Gallus gallus)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Gallus gallus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Gallus gallus)
        
        Regulation of NF-kappa B signaling (Gallus gallus)
        
        CASP8 cleaves N4BP1 at D424, D490 (Gallus gallus)
        
        active caspase-8 [cytosol] (Gallus gallus)
        
        Caspase-8 dimer [cytosol] (Gallus gallus)
        
        CASP8 [cytosol] (Gallus gallus)
        
        N4BP1 binds IKBKG (Gallus gallus)
        
        active caspase-8 [cytosol] (Gallus gallus)
        
        Caspase-8 dimer [cytosol] (Gallus gallus)
        
        CASP8 [cytosol] (Gallus gallus)
        
        TRIF-mediated programmed cell death (Gallus gallus)
        
        Caspase-8 processing within TLR4 complex (Gallus gallus)
        
        active caspase-8 [cytosol] (Gallus gallus)
        
        Caspase-8 dimer [cytosol] (Gallus gallus)
        
        CASP8 [cytosol] (Gallus gallus)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Gallus gallus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Gallus gallus)
        
        Regulation of NF-kappa B signaling (Gallus gallus)
        
        CASP8 cleaves N4BP1 at D424, D490 (Gallus gallus)
        
        active caspase-8 [cytosol] (Gallus gallus)
        
        Caspase-8 dimer [cytosol] (Gallus gallus)
        
        CASP8 [cytosol] (Gallus gallus)
        
        N4BP1 binds IKBKG (Gallus gallus)
        
        active caspase-8 [cytosol] (Gallus gallus)
        
        Caspase-8 dimer [cytosol] (Gallus gallus)
        
        CASP8 [cytosol] (Gallus gallus)
    - Toll Like Receptor 5 (TLR5) Cascade (Gallus gallus)
      - MyD88 cascade initiated on plasma membrane (Gallus gallus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Gallus gallus)
        
        Regulation of NF-kappa B signaling (Gallus gallus)
        
        CASP8 cleaves N4BP1 at D424, D490 (Gallus gallus)
        
        active caspase-8 [cytosol] (Gallus gallus)
        
        Caspase-8 dimer [cytosol] (Gallus gallus)
        
        CASP8 [cytosol] (Gallus gallus)
        
        N4BP1 binds IKBKG (Gallus gallus)
        
        active caspase-8 [cytosol] (Gallus gallus)
        
        Caspase-8 dimer [cytosol] (Gallus gallus)
        
        CASP8 [cytosol] (Gallus gallus)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Gallus gallus)
      - MyD88 dependent cascade initiated on endosome (Gallus gallus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Gallus gallus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Gallus gallus)
        
        Regulation of NF-kappa B signaling (Gallus gallus)
        
        CASP8 cleaves N4BP1 at D424, D490 (Gallus gallus)
        
        active caspase-8 [cytosol] (Gallus gallus)
        
        Caspase-8 dimer [cytosol] (Gallus gallus)
        
        CASP8 [cytosol] (Gallus gallus)
        
        N4BP1 binds IKBKG (Gallus gallus)
        
        active caspase-8 [cytosol] (Gallus gallus)
        
        Caspase-8 dimer [cytosol] (Gallus gallus)
        
        CASP8 [cytosol] (Gallus gallus)
    - Toll Like Receptor 9 (TLR9) Cascade (Gallus gallus)
      - MyD88 dependent cascade initiated on endosome (Gallus gallus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Gallus gallus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Gallus gallus)
        
        Regulation of NF-kappa B signaling (Gallus gallus)
        
        CASP8 cleaves N4BP1 at D424, D490 (Gallus gallus)
        
        active caspase-8 [cytosol] (Gallus gallus)
        
        Caspase-8 dimer [cytosol] (Gallus gallus)
        
        CASP8 [cytosol] (Gallus gallus)
        
        N4BP1 binds IKBKG (Gallus gallus)
        
        active caspase-8 [cytosol] (Gallus gallus)
        
        Caspase-8 dimer [cytosol] (Gallus gallus)
        
        CASP8 [cytosol] (Gallus gallus)

External Reference Information

External Reference

UniProt:A0A8V0ZVJ3

Gene Names

CASP8

Reference Genes

ENSEMBL:ENSGALG00010024903.1

UCSC:A0A8V0ZVJ3 CASP8

Other Identifiers

395284

GO:0004197

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0006508

GO:0006915

GO:0006954

GO:0008233

GO:0008234

GO:0008625

GO:0010467

GO:0016787

GO:0030027

GO:0030154

GO:0030225

GO:0030335

GO:0031264

GO:0031265

GO:0031625

GO:0032731

GO:0032991

GO:0034612

GO:0035877

GO:0036462

GO:0042802

GO:0042981

GO:0043123

GO:0043124

GO:0043525

GO:0045651

GO:0045862

GO:0051603

GO:0051604

GO:0060546

GO:0070269

GO:0071260

GO:0097110

GO:0097190

GO:0097191

GO:0097194

GO:0097342

GO:0140639

GO:1900119

GT_A_87_P193368

Gga.2451.1.S1_at

Participates

as a component of

Caspase-8 dimer [cytosol] (Gallus gallus)

Other forms of this molecule

CASP8 [cytosol]

CASP8 [mitochondrial outer membrane]

CASP8 [cytosol]

Inferred From

CASP8(385-479) [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSGALG00010024903, ENSGALP00010037578, ENSGALT00010060819

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