Assembly of telomerase and telomere extension

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Gallus gallus
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Telomerase activity has been demonstrated in a variety of chicken cells in vivo and in vitro including primary, differentiated, aging, immortalized and transformed cell types (Taylor and Delany 2000; Swanberg and Delany 2003; O'Hare and Delany 2005; Hrdlickova et al. 2006).

The telomerase ribonucleoprotein complex is formed in the nucleoplasm from the association of TERT and TERC. In human, DKC1 (dyskerin) is also part of the complex, but association of the chicken ortholog with chicken telomerase has not been demonstrated experimentally. The involvement and stoichiometry of DKC1 as a component of the complex in chicken are inferred from studies of purified human telomerase (Cohen et al. 2007).

RUVBL1 (pontin) and RUVBL2 (reptin) are found associated with human telomerase purified from HeLa cells and activities of these proteins are required for telomerase assembly in vitro (Venteicher et al. 2008). Their exact roles in the assembly and function of in vivo telomerase remain unclear. A potential chicken ortholog for RUVBL1 (pontin) has been identified.

NHP2 (NOLA2) is likewise associated with telomerase ribonucleoprotein complexes (Pogacic et al. 2000) and homozygous NHP2 mutations are associated with telomerase failure in humans (Vuillamy et al. 2008). A potential chicken ortholog for NHP2 has been identified.

Literature References
PubMed ID Title Journal Year
18358808 Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly

Venteicher, AS, Veenstra, TD, Artandi, SE, Mason, PJ, Meng, Z

Cell 2008
14970723 Dynamics of telomere erosion in transformed and non-transformed avian cells in vitro

Delany, ME, Swanberg, SE

Cytogenet Genome Res 2003
11074001 Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10

Filipowicz, W, Pogacic, V, Dragon, F

Mol Cell Biol 2000
23598659 Telomerase gene expression in the chicken: Telomerase RNA (TR) and reverse transcriptase (TERT) transcript profiles are tissue-specific and correlate with telomerase activity

Delany, ME, O'Hare, TH

Age (Dordr) 2005
18523010 Mutations in the telomerase component NHP2 cause the premature ageing syndrome dyskeratosis congenita

Kirwan, M, Marrone, A, Walne, A, Digweed, M, Beswick, R, Vulliamy, T, Dokal, I

Proc Natl Acad Sci U S A 2008
16352553 Mechanism of telomerase activation by v-Rel and its contribution to transformation

Hrdlickova, R, Liss, AS, Bose, HR, Nehyba, J

J Virol 2006
17395830 Protein composition of catalytically active human telomerase from immortal cells

Reddel, RR, Lovrecz, GO, Bache, N, Graham, ME, Cohen, SB, Robinson, PJ

Science 2007
11142683 Ontogeny of telomerase in chicken: impact of downregulation on pre- and postnatal telomere length in vivo

Taylor, HA, Delany, ME

Dev Growth Differ 2000
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