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Dissociation of telomerase RNP from the extended chromosomal end
Stable Identifier
R-GGA-418082
Type
Reaction [dissociation]
Species
Gallus gallus
Compartment
nucleoplasm
Synonyms
telomerase RNP:G-strand complex with two added single-stranded repeats => telomerase RNP + G-strand with two added single-stranded repeats
ReviewStatus
5/5
Locations in the PathwayBrowser
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DNA replication and repair (Gallus gallus)
Telomere maintenance (Gallus gallus)
Assembly of telomerase and telomere extension (Gallus gallus)
Dissociation of telomerase RNP from the extended chromosomal end (Gallus gallus)
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The process by which extension of a telomere is terminated has not been characterized in chicken cells, but is inferred from the human system. Human telomerase RNP has low processivity and can dissociate from the primer after addition of single nucleotides or whole repeat units in vitro. Regulation of this process is not well understood, but PIF1 protein, a helicase, can promote dissociation in vitro and its expression levels are inversely correlated with telomere length in some tissue culture systems (Boule et al. 2005; Zhang et al. 2006). On this basis, PIF1 is annotated here as a positive regulator of telomere – telomerase dissociation.
Literature References
PubMed ID
Title
Journal
Year
16522649
The human Pif1 helicase, a potential Escherichia coli RecD homologue, inhibits telomerase activity
Huang, Y
,
Xu, LX
,
Zhou, B
,
Zhang, DH
,
Zhou, JQ
Nucleic Acids Res
2006
16121131
The yeast Pif1p helicase removes telomerase from telomeric DNA
Vega, LR
,
Boule, JB
,
Zakian, VA
Nature
2005
Participants
Input
telomerase RNP:G-strand complex with two added single-stranded repeats [nucleoplasm]
(Gallus gallus)
Output
G-strand Chromosome end with two additional single strand repeats - Telomeric [nucleoplasm]
telomerase RNP [nucleoplasm]
(Gallus gallus)
Participates
as an event of
Assembly of telomerase and telomere extension (Gallus gallus)
This event is regulated
Positively by
Regulator
PIF1 [nucleoplasm]
(Gallus gallus)
Inferred From
Disassociation of Telomerase RNP and the Chromosome End (Homo sapiens)
Authored
Delany, ME (2010-06-11)
Swanberg, SE (2010-06-11)
O'Hare, TH (2010-06-11)
Created
D'Eustachio, P (2009-04-15)
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