Dissociation of telomerase RNP from the extended chromosomal end

Stable Identifier
Reaction [dissociation]
Gallus gallus
telomerase RNP:G-strand complex with two added single-stranded repeats => telomerase RNP + G-strand with two added single-stranded repeats
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The process by which extension of a telomere is terminated has not been characterized in chicken cells, but is inferred from the human system. Human telomerase RNP has low processivity and can dissociate from the primer after addition of single nucleotides or whole repeat units in vitro. Regulation of this process is not well understood, but PIF1 protein, a helicase, can promote dissociation in vitro and its expression levels are inversely correlated with telomere length in some tissue culture systems (Boule et al. 2005; Zhang et al. 2006). On this basis, PIF1 is annotated here as a positive regulator of telomere – telomerase dissociation.
Literature References
PubMed ID Title Journal Year
16522649 The human Pif1 helicase, a potential Escherichia coli RecD homologue, inhibits telomerase activity

Huang, Y, Xu, LX, Zhou, B, Zhang, DH, Zhou, JQ

Nucleic Acids Res 2006
16121131 The yeast Pif1p helicase removes telomerase from telomeric DNA

Vega, LR, Boule, JB, Zakian, VA

Nature 2005
This event is regulated
Positively by
Inferred From
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