Association of Ku heterodimer with ends of DNA double-strand breaks

Stable Identifier
R-GGA-353226
Type
Reaction [binding]
Species
Gallus gallus
Compartment
nucleoplasm
ReviewStatus
5/5
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Association of Ku heterodimer with ends of DNA double-strand breaks
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A DNA double strand break results when two single strand breaks (i.e. cleavage of the phosphodiester backbone) occur within a 10 bp distance. The Ku70/80 heterodimer binds to the ends of the double strand break. Ku can then translocate inwards from the site of the break in an ATP-independent manner.
Literature References
PubMed ID Title Journal Year
9736627 Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

Takata, M, Sasaki, MS, Sonoda, E, Morrison, C, Hashimoto, M, Utsumi, H, Yamaguchi-Iwai, Y, Shinohara, A, Takeda, S

EMBO J 1998
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Authored
Saxena, A  (2008-07-07)
Reviewed
Borowiec, JA  (2009-04-24)
Created
Saxena, A  (2008-06-12)
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