It has been suggested that large prodomains with DED (death effector domains) of caspases-8/10 can function as a bridge to link downstream mediators like IKK complex to the adaptor proteins [Chaudhary PM et al 2000, Lamkanfi M et al 2006]. Recruitment of caspases-8/10 to activated receptor complex is also believed to result in conformational changes leading to caspase auto-proteolysis. Processed caspases were shown to activate NF-kB signaling. However, the detailed mechanism of caspase-mediated NF-kB induction remains unclear [Takahashi K et al 2006, Lamkanfi M et al 2006].
Kawai, T, Sato, S, Kumar, H, Akira, S, Yonehara, S, Takahashi, K
Vandenabeele, P, Vanden Berghe, T, Lamkanfi, M, Declercq, W
Miyashita, T, Shikama, Y, Yamada, M
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