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Recruitment of IKK complex
Stable Identifier
R-GGA-1227755
Type
Reaction [binding]
Species
Gallus gallus
Related Species
Infectious bronchitis virus
Compartment
mitochondrial outer membrane
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Innate Immune System (Gallus gallus)
RLR (RIG-like receptor) mediated induction of IFN alpha/beta (Gallus gallus)
Caspase-8 and -10 mediated induction of NF-kB (Gallus gallus)
Recruitment of IKK complex (Gallus gallus)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In mammals, IKKs (IkB kinase complex) were shown to interact with DED-containing prodomains of caspases-8/10 resulting in NFkB activation
Literature References
PubMed ID
Title
Journal
Year
11002417
Activation of the NF-kappaB pathway by caspase 8 and its homologs
Eby, MT
,
Liu, L
,
Hood, L
,
Kumar, A
,
Chaudhary, PM
,
Jasmin, A
Oncogene
2000
Participants
Input
dsRNA:MDA5:IPS1:TRADD:FADD:RIP1:procaspase 8 or 10 dimer [mitochondrial outer membrane]
(Gallus gallus)
IKKs_complex (Inhibitor of kappa B kinases) [cytosol]
(Gallus gallus)
Output
dsRNA:MDA5:IPS1:TRADD:FADD:RIP1:caspase8 or 10 dimer:IKKcomplex [mitochondrial outer membrane]
(Gallus gallus)
Participates
as an event of
Caspase-8 and -10 mediated induction of NF-kB (Gallus gallus)
Inferred From
Recruitment of IKK complex (Homo sapiens)
Authored
Shamovsky, V (2011-01-05)
Reviewed
Garapati, P V (2011-05-16)
Created
Shamovsky, V (2011-03-10)
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