IPS1 interacts with TRADD, RIP1 and FADD

Stable Identifier
R-GGA-1227732
Type
Reaction [binding]
Species
Gallus gallus
Related Species
Infectious bronchitis virus
Compartment
cytosol, mitochondrial outer membrane
ReviewStatus
5/5
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IPS1 interacts with TRADD, RIP1 and FADD
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Mammalian IPS-1 was shown to interact with death domain (DD)-containing proteins FADD (Fas-associated death domain), RIP-1(receptor-interacting protein)and TRADD (TNFR-associated death domain) to mediate NFkB activation.
Literature References
PubMed ID Title Journal Year
19295631 Death receptor signal transducers: nodes of coordination in immune signaling networks

Wilson, NS, Ashkenazi, A, Dixit, V

Nat Immunol 2009
15549108 A FADD-dependent innate immune mechanism in mammalian cells

Thomas, E, Barber, GN, Balachandran, S

Nature 2004
18439848 TRADD protein is an essential component of the RIG-like helicase antiviral pathway

Bscheider, M, Rebsamen, M, Poeck, H, Tschopp, J, Ermolaeva, MA, Curran, J, Vazquez, J, Michallet, MC, Kalinke, U, Meylan, E, Hartmann, G, Pasparakis, M, König, M

Immunity 2008
16127453 IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

Takeuchi, O, Ishii, KJ, Kumar, H, Sato, S, Kawai, T, Takahashi, K, Kato, H, Coban, C

Nat Immunol 2005
Participants
Input
Output
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as an event of
Inferred From
MAVS interacts with RIPK1 and FADD (Homo sapiens)
Authored
Shamovsky, V  (2011-01-05)
Reviewed
Garapati, P V  (2011-05-16)
Created
Shamovsky, V  (2011-03-10)
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