Reactome | hbegfa [extracellular region]

hbegfa [extracellular region]

Stable Identifier

R-DRE-1233234

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

extracellular region

Synonyms

HBEGF(63-148), A9JRW9

Locations in the PathwayBrowser

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Signal Transduction (Danio rerio)

- Intracellular signaling by second messengers (Danio rerio)
  - PIP3 activates AKT signaling (Danio rerio)
    - Negative regulation of the PI3K/AKT network (Danio rerio)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Danio rerio)
        
        PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
        
        Activator:PI3K [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Danio rerio)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        PI3K:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Danio rerio)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
    - PI3K phosphorylates PIP2 to PIP3 (Danio rerio)
      - Activator:PI3K [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Danio rerio)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        PI3K:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Danio rerio)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
- MAPK family signaling cascades (Danio rerio)
  - MAPK1/MAPK3 signaling (Danio rerio)
    - RAF/MAP kinase cascade (Danio rerio)
      - RAS GEFs promote RAS nucleotide exchange (Danio rerio)
        
        RAS GEFs [plasma membrane] (Danio rerio)
        
        GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] (Danio rerio)
        
        HB-EGF:p-6Y-EGFR dimer [plasma membrane] (Danio rerio)
        
        HB-EGF:p-6Y-EGFR [plasma membrane] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        p-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Danio rerio)
        
        p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Danio rerio)
        
        p-ERBB4 homodimers [plasma membrane] (Danio rerio)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Danio rerio)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-ERBB4jmAcyt2 homodimer [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Danio rerio)
        
        Phosphorylated ERBB2:ERBB4 heterodimers [plasma membrane] (Danio rerio)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        Phosphorylated ERBB2:ERBB4cyt2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
- Signaling by GPCR (Danio rerio)
  - GPCR downstream signalling (Danio rerio)
    - G alpha (q) signalling events (Danio rerio)
      - Gastrin-CREB signalling pathway via PKC and MAPK (Danio rerio)
        
        EGFR Transactivation by Gastrin (Danio rerio)
        
        GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Danio rerio)
        
        GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] (Danio rerio)
        
        HB-EGF:p-6Y-EGFR dimer [plasma membrane] (Danio rerio)
        
        HB-EGF:p-6Y-EGFR [plasma membrane] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        HB-EGF:p-6Y-EGFR dimer [plasma membrane] (Danio rerio)
        
        HB-EGF:p-6Y-EGFR [plasma membrane] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Danio rerio)
        
        HB-EGF:p-6Y-EGFR dimer [plasma membrane] (Danio rerio)
        
        HB-EGF:p-6Y-EGFR [plasma membrane] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Danio rerio)
        
        GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] (Danio rerio)
        
        HB-EGF:p-6Y-EGFR dimer [plasma membrane] (Danio rerio)
        
        HB-EGF:p-6Y-EGFR [plasma membrane] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
- Signaling by Non-Receptor Tyrosine Kinases (Danio rerio)
  - Signaling by PTK6 (Danio rerio)
    - ERBB2 Activates PTK6 Signaling (Danio rerio)
      - Activated ERBB2 binds PTK6 (BRK) (Danio rerio)
        
        p-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-ERBB2 heterodimers:PTK6 [plasma membrane] (Danio rerio)
        
        p-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
      - ERBB2 promotes PTK6 autophosphorylation (Danio rerio)
        
        p-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-ERBB2 heterodimers:PTK6 [plasma membrane] (Danio rerio)
        
        p-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
- Signaling by Nuclear Receptors (Danio rerio)
  - ESR-mediated signaling (Danio rerio)
    - Extra-nuclear estrogen signaling (Danio rerio)
      - MMPs cleave HB-EGF (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
- Signaling by Receptor Tyrosine Kinases (Danio rerio)
  - Signaling by ERBB2 (Danio rerio)
    - Downregulation of ERBB2 signaling (Danio rerio)
      - PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Danio rerio)
        
        Heterodimers of p-ERBB2 dephosphorylated at Y1248 [plasma membrane] (Danio rerio)
        
        Phosphorylated p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        Phosphorylated p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
    - ERBB2 Activates PTK6 Signaling (Danio rerio)
      - Activated ERBB2 binds PTK6 (BRK) (Danio rerio)
        
        p-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-ERBB2 heterodimers:PTK6 [plasma membrane] (Danio rerio)
        
        p-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
      - ERBB2 promotes PTK6 autophosphorylation (Danio rerio)
        
        p-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-ERBB2 heterodimers:PTK6 [plasma membrane] (Danio rerio)
        
        p-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
    - ERBB2 Regulates Cell Motility (Danio rerio)
      - Phosphorylated ERBB2 heterodimers bind MEMO1 (Danio rerio)
        
        p-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Danio rerio)
        
        p-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
    - GRB2 events in ERBB2 signaling (Danio rerio)
      - GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Danio rerio)
        
        Phosphorylated ERBB2:ERBB4 heterodimers [plasma membrane] (Danio rerio)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        Phosphorylated ERBB2:ERBB4cyt2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        Phosphorylated ERBB2:ERBB4 heterodimers [plasma membrane] (Danio rerio)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        Phosphorylated ERBB2:ERBB4cyt2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
      - RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Danio rerio)
        
        Phosphorylated ERBB2:ERBB4 heterodimers [plasma membrane] (Danio rerio)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        Phosphorylated ERBB2:ERBB4cyt2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
    - PI3K events in ERBB2 signaling (Danio rerio)
      - Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Danio rerio)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
      - PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Danio rerio)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
    - SHC1 events in ERBB2 signaling (Danio rerio)
      - SHC1 phosphorylation by ERBB2 heterodimers (Danio rerio)
        
        SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        p-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        p-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
    - SRC family kinases phosphorylate ERBB2 (Danio rerio)
      - ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:ERBB4:ERBB2 [plasma membrane] (Danio rerio)
        
        ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        ERBB2:ERBB4cyt2 heterodimer [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
      - p-Y877-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:ERBB4:p-Y877-ERBB2 [plasma membrane] (Danio rerio)
        
        p-Y877-ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-Y877-ERBB2:ERBB4cyt2 heterodimer [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
    - Trans-autophosphorylation of ERBB2 heterodimers (Danio rerio)
      - ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:ERBB4:ERBB2 [plasma membrane] (Danio rerio)
        
        ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        ERBB2:ERBB4cyt2 heterodimer [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
      - p-6Y-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-6Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
    - Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Danio rerio)
      - Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGFLs:p-ERBB4cyt2:p-7Y-ERBB2 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
      - p-Y877-ERBB2 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGFLs:ERBB4:p-Y877-ERBB2 [plasma membrane] (Danio rerio)
        
        p-Y877-ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-Y877-ERBB2:ERBB4cyt2 heterodimer [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
  - Signaling by ERBB4 (Danio rerio)
    - ERBB4 binds NRGs or EGF-like ligands (Danio rerio)
      - EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
      - NRGs/EGF-like ligands:ERBB4 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
    - ERBB4 forms heterodimers with ERBB3 (Danio rerio)
      - ERBB4:ERBB3 heterodimer [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:ERBB4 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
      - NRGs/EGF-like ligands:ERBB4 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
    - Homodimerization of ERBB4 (Danio rerio)
      - ERBB4 homodimers [plasma membrane] (Danio rerio)
        
        ERBB4cyt1 homodimers [plasma membrane] (Danio rerio)
        
        ERBB4jmAcyt1 homodimer [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        ERBB4jmBcyt1 homodimer [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        ERBB4jmAcyt2 homodimer [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
      - NRGs/EGF-like ligands:ERBB4 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
    - PI3K events in ERBB4 signaling (Danio rerio)
      - Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Danio rerio)
        
        PI3K:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Danio rerio)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Danio rerio)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
      - Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Danio rerio)
        
        PI3K:p-ERBB4cyt1 [plasma membrane] (Danio rerio)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Danio rerio)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
    - SHC1 events in ERBB4 signaling (Danio rerio)
      - RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Danio rerio)
        
        GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Danio rerio)
        
        p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Danio rerio)
        
        p-ERBB4 homodimers [plasma membrane] (Danio rerio)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Danio rerio)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-ERBB4jmAcyt2 homodimer [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
    - Trans-autophosphorylation of ERBB4 homodimers (Danio rerio)
      - ERBB4 homodimers [plasma membrane] (Danio rerio)
        
        ERBB4cyt1 homodimers [plasma membrane] (Danio rerio)
        
        ERBB4jmAcyt1 homodimer [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        ERBB4jmBcyt1 homodimer [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:ERBB4jmBcyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        ERBB4jmAcyt2 homodimer [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:ERBB4jmAcyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
      - p-ERBB4 homodimers [plasma membrane] (Danio rerio)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Danio rerio)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:P-ERBB4jmAcyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-ERBB4jmBcyt1 [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:P-ERBB4jmBcyt1 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)
        
        p-ERBB4jmAcyt2 homodimer [plasma membrane] (Danio rerio)
        
        NRGs/EGF-like ligands:p-ERBB4cyt2 [plasma membrane] (Danio rerio)
        
        EGF-like ligands [extracellular region] (Danio rerio)
        
        hbegfa [extracellular region] (Danio rerio)

External Reference Information

External Reference

UniProt:A9JRW9

Gene Names

hbegfa

Reference Genes

BioGPS Gene:797938 hbegfa

CTD Gene:797938 hbegfa

ENSEMBL:ENSDARG00000075121

KEGG:dre:797938 hbegfa

Monarch:797938 hbegfa

NCBI Entrez Gene:797938 hbegfa

UCSC:A9JRW9 hbegfa

Reference Transcript

RefSeq:NM_001111226.1 hbegfa

Other Identifiers

13007900

797938

A_15_P117411

A_15_P405805

A_15_P415285

A_15_P486475

A_15_P734371

CJ007041

CJ007042

CUST_1244_PI428451958

DRER17837

DRER47144

Dr.16053.1.S1_at

ENSDART00000109138

GT_Spec_NM_001111226.1_198315

JP007439

JP007440

ZV700S00001990

Participates

as an output of

MMPs cleave HB-EGF (Danio rerio)

as a component of

as an input of

Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor (Danio rerio)

as a member of

EGF-like ligands [extracellular region] (Danio rerio)

Other forms of this molecule

hbegfa [plasma membrane]

hbegfa [endoplasmic reticulum membrane]

hbegfa [ER to Golgi transport vesicle membrane]

hbegfa [plasma membrane]

hbegfa [extracellular region]

Inferred From

HBEGF(63-148) [extracellular region] (Homo sapiens)

Cross References

RefSeq

NP_001104696.1

ENSEMBL

ENSDART00000109138, ENSDARG00000075121, ENSDARP00000099541

ZFIN

ZDB-GENE-080204-119

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