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phospho-K63polyUb-hp-IRAK1 [cytosol]
Stable Identifier
R-DRE-451565
Type
Protein [EntityWithAccessionedSequence]
Species
Danio rerio
Compartment
cytosol
Synonyms
F6NJE2
Locations in the PathwayBrowser
Expand all
Immune System (Danio rerio)
Cytokine Signaling in Immune system (Danio rerio)
Signaling by Interleukins (Danio rerio)
Interleukin-1 family signaling (Danio rerio)
Interleukin-1 signaling (Danio rerio)
K63polyUb-IRAK1 dissociates (Danio rerio)
K63polyUb-hp-IRAK1:p-Pellino-1,2,(3):UBE2N:UBE2V1 [cytosol] (Danio rerio)
K63polyUb-hp-IRAK1:p-Pellino-1,2,(3) [cytosol] (Danio rerio)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Danio rerio)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Danio rerio)
NEMO binds polyubiquitinated IRAK1 (Danio rerio)
Poly-K6-Ub-hp-IRAK1:CHUK:IKBKB:IKBKG [cytosol] (Danio rerio)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Danio rerio)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Danio rerio)
Pellino ubiquitinates IRAK1 (Danio rerio)
K63polyUb-hp-IRAK1:p-Pellino-1,2,(3):UBE2N:UBE2V1 [cytosol] (Danio rerio)
K63polyUb-hp-IRAK1:p-Pellino-1,2,(3) [cytosol] (Danio rerio)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Danio rerio)
Innate Immune System (Danio rerio)
Toll-like Receptor Cascades (Danio rerio)
Toll Like Receptor 10 (TLR10) Cascade (Danio rerio)
MyD88 cascade initiated on plasma membrane (Danio rerio)
IRAK1 recruits IKK complex (Danio rerio)
NEMO subunit of IKK complex binds to activated IRAK1 (Danio rerio)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Danio rerio)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Danio rerio)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Danio rerio)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Danio rerio)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Danio rerio)
Pellino ubiquitinates hp-IRAK1 (Danio rerio)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Danio rerio)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Danio rerio)
Toll Like Receptor 2 (TLR2) Cascade (Danio rerio)
Toll Like Receptor TLR1:TLR2 Cascade (Danio rerio)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
IRAK1 recruits IKK complex (Danio rerio)
NEMO subunit of IKK complex binds to activated IRAK1 (Danio rerio)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Danio rerio)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Danio rerio)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Danio rerio)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Danio rerio)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Danio rerio)
Pellino ubiquitinates hp-IRAK1 (Danio rerio)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Danio rerio)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Danio rerio)
Toll Like Receptor TLR6:TLR2 Cascade (Danio rerio)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
IRAK1 recruits IKK complex (Danio rerio)
NEMO subunit of IKK complex binds to activated IRAK1 (Danio rerio)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Danio rerio)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Danio rerio)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Danio rerio)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Danio rerio)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Danio rerio)
Pellino ubiquitinates hp-IRAK1 (Danio rerio)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Danio rerio)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Danio rerio)
Toll Like Receptor 4 (TLR4) Cascade (Danio rerio)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
IRAK1 recruits IKK complex (Danio rerio)
NEMO subunit of IKK complex binds to activated IRAK1 (Danio rerio)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Danio rerio)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Danio rerio)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Danio rerio)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Danio rerio)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Danio rerio)
Pellino ubiquitinates hp-IRAK1 (Danio rerio)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Danio rerio)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Danio rerio)
Toll Like Receptor 5 (TLR5) Cascade (Danio rerio)
MyD88 cascade initiated on plasma membrane (Danio rerio)
IRAK1 recruits IKK complex (Danio rerio)
NEMO subunit of IKK complex binds to activated IRAK1 (Danio rerio)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Danio rerio)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Danio rerio)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Danio rerio)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Danio rerio)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Danio rerio)
Pellino ubiquitinates hp-IRAK1 (Danio rerio)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Danio rerio)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Danio rerio)
External Reference Information
External Reference
UniProt:F6NJE2
Reference Genes
BioGPS Gene:569226
ENSEMBL:ENSDARG00000025949
KEGG:dre:569226
Monarch:569226
NCBI Gene:569226
UCSC:F6NJE2
Reference Transcript
RefSeq:XM_068223097.1
RefSeq:XM_005166703.5
Other Identifiers
13250530
13280822
13284672
569226
A_15_P188806
A_15_P219946
A_15_P519417
CJ002523
CJ014470
CUST_9493_PI428451953
CUST_9494_PI428451953
CUST_9495_PI428451953
DRER15753
DRER37061
DRER37860
ENSDART00000035931
ENSDART00000035931_1
ENSDART00000035931_2
ENSDART00000101527
GO:0003824
GO:0004672
GO:0005515
GO:0005524
GO:0006468
GO:0007165
GO:0016740
GO:0140096
GT_Xhyb_XM_005166703.1_137956
GT_Xhyb_XM_692596.6_72741
JP002712
XM_681279
XM_692596
Participates
as an output of
K63polyUb-IRAK1 dissociates (Danio rerio)
as a component of
K63polyUb-hp-IRAK1:p-Pellino-1,2,(3) [cytosol] (Danio rerio)
Poly-K6-Ub-hp-IRAK1:CHUK:IKBKB:IKBKG [cytosol] (Danio rerio)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Danio rerio)
as an input of
NEMO binds polyubiquitinated IRAK1 (Danio rerio)
Other forms of this molecule
phospho-K63polyUb-hp-IRAK1 [endosome membrane]
phospho-p-S,T-IRAK1 [cytosol]
phospho-p-IRAK2 [endosome membrane]
phospho-p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]
phospho-p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]
phospho-p-IRAK2 [plasma membrane]
phospho-p-2S,S376,T,T209,T387-IRAK1 [cytosol]
phospho-p-IRAK2 [cytosol]
Inferred From
K63polyUb-hp-IRAK1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 209 (in Homo sapiens)
Coordinate
209
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 376 (in Homo sapiens)
Coordinate
376
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 387 (in Homo sapiens)
Coordinate
387
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at unknown position
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 134 (in Homo sapiens)
Coordinate
134
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 160 (in Homo sapiens)
Coordinate
160
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
XP_068079198.1
,
XP_005166760.1
ENSEMBL
ENSDARP00000118154
,
ENSDARG00000025949
,
ENSDART00000137975
ZFIN
ZDB-GENE-071116-5
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