Reactome | phospho-p-IRAK2 [cytosol]

phospho-p-IRAK2 [cytosol]

Stable Identifier

R-DRE-446636

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

cytosol

Synonyms

F6NJE2

Locations in the PathwayBrowser

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Immune System (Danio rerio)

- Cytokine Signaling in Immune system (Danio rerio)
  - Signaling by Interleukins (Danio rerio)
    - Interleukin-1 family signaling (Danio rerio)
      - Interleukin-1 signaling (Danio rerio)
        
        TAK1-dependent IKK and NF-kappa-B activation (Danio rerio)
        
        Ubiquitination of IKBKG by TRAF6 (Danio rerio)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        phospho-p-IRAK2 [cytosol] (Danio rerio)
    - Interleukin-17 signaling (Danio rerio)
      - MAP kinase activation (Danio rerio)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Danio rerio)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        phospho-p-IRAK2 [cytosol] (Danio rerio)
        
        activated TAK1 mediates p38 MAPK activation (Danio rerio)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        phospho-p-IRAK2 [cytosol] (Danio rerio)
- Innate Immune System (Danio rerio)
  - Toll-like Receptor Cascades (Danio rerio)
    - Toll Like Receptor 10 (TLR10) Cascade (Danio rerio)
      - MyD88 cascade initiated on plasma membrane (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Danio rerio)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        phospho-p-IRAK2 [cytosol] (Danio rerio)
        
        activated TAK1 mediates p38 MAPK activation (Danio rerio)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        phospho-p-IRAK2 [cytosol] (Danio rerio)
        
        TAK1-dependent IKK and NF-kappa-B activation (Danio rerio)
        
        Ubiquitination of IKBKG by TRAF6 (Danio rerio)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        phospho-p-IRAK2 [cytosol] (Danio rerio)
    - Toll Like Receptor 2 (TLR2) Cascade (Danio rerio)
      - Toll Like Receptor TLR1:TLR2 Cascade (Danio rerio)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Danio rerio)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        phospho-p-IRAK2 [cytosol] (Danio rerio)
        
        activated TAK1 mediates p38 MAPK activation (Danio rerio)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        phospho-p-IRAK2 [cytosol] (Danio rerio)
        
        TAK1-dependent IKK and NF-kappa-B activation (Danio rerio)
        
        Ubiquitination of IKBKG by TRAF6 (Danio rerio)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        phospho-p-IRAK2 [cytosol] (Danio rerio)
      - Toll Like Receptor TLR6:TLR2 Cascade (Danio rerio)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Danio rerio)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        phospho-p-IRAK2 [cytosol] (Danio rerio)
        
        activated TAK1 mediates p38 MAPK activation (Danio rerio)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        phospho-p-IRAK2 [cytosol] (Danio rerio)
        
        TAK1-dependent IKK and NF-kappa-B activation (Danio rerio)
        
        Ubiquitination of IKBKG by TRAF6 (Danio rerio)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        phospho-p-IRAK2 [cytosol] (Danio rerio)
    - Toll Like Receptor 3 (TLR3) Cascade (Danio rerio)
      - MAP kinase activation (Danio rerio)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Danio rerio)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        phospho-p-IRAK2 [cytosol] (Danio rerio)
        
        activated TAK1 mediates p38 MAPK activation (Danio rerio)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        phospho-p-IRAK2 [cytosol] (Danio rerio)
      - TAK1-dependent IKK and NF-kappa-B activation (Danio rerio)
        
        Ubiquitination of IKBKG by TRAF6 (Danio rerio)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        phospho-p-IRAK2 [cytosol] (Danio rerio)
    - Toll Like Receptor 4 (TLR4) Cascade (Danio rerio)
      - MyD88-independent TLR4 cascade (Danio rerio)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Danio rerio)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        phospho-p-IRAK2 [cytosol] (Danio rerio)
        
        activated TAK1 mediates p38 MAPK activation (Danio rerio)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        phospho-p-IRAK2 [cytosol] (Danio rerio)
        
        TAK1-dependent IKK and NF-kappa-B activation (Danio rerio)
        
        Ubiquitination of IKBKG by TRAF6 (Danio rerio)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        phospho-p-IRAK2 [cytosol] (Danio rerio)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Danio rerio)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        phospho-p-IRAK2 [cytosol] (Danio rerio)
        
        activated TAK1 mediates p38 MAPK activation (Danio rerio)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        phospho-p-IRAK2 [cytosol] (Danio rerio)
        
        TAK1-dependent IKK and NF-kappa-B activation (Danio rerio)
        
        Ubiquitination of IKBKG by TRAF6 (Danio rerio)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        phospho-p-IRAK2 [cytosol] (Danio rerio)
    - Toll Like Receptor 5 (TLR5) Cascade (Danio rerio)
      - MyD88 cascade initiated on plasma membrane (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Danio rerio)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        phospho-p-IRAK2 [cytosol] (Danio rerio)
        
        activated TAK1 mediates p38 MAPK activation (Danio rerio)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        phospho-p-IRAK2 [cytosol] (Danio rerio)
        
        TAK1-dependent IKK and NF-kappa-B activation (Danio rerio)
        
        Ubiquitination of IKBKG by TRAF6 (Danio rerio)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        phospho-p-IRAK2 [cytosol] (Danio rerio)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Danio rerio)
      - MyD88 dependent cascade initiated on endosome (Danio rerio)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Danio rerio)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        phospho-p-IRAK2 [cytosol] (Danio rerio)
        
        activated TAK1 mediates p38 MAPK activation (Danio rerio)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        phospho-p-IRAK2 [cytosol] (Danio rerio)
        
        TAK1-dependent IKK and NF-kappa-B activation (Danio rerio)
        
        Ubiquitination of IKBKG by TRAF6 (Danio rerio)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        phospho-p-IRAK2 [cytosol] (Danio rerio)
    - Toll Like Receptor 9 (TLR9) Cascade (Danio rerio)
      - MyD88 dependent cascade initiated on endosome (Danio rerio)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Danio rerio)
        
        MAP kinase activation (Danio rerio)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Danio rerio)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        phospho-p-IRAK2 [cytosol] (Danio rerio)
        
        activated TAK1 mediates p38 MAPK activation (Danio rerio)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Danio rerio)
        
        Activated TAK complexes [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        phospho-p-IRAK2 [cytosol] (Danio rerio)
        
        TAK1-dependent IKK and NF-kappa-B activation (Danio rerio)
        
        Ubiquitination of IKBKG by TRAF6 (Danio rerio)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Danio rerio)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)
        
        phospho-p-IRAK2 [cytosol] (Danio rerio)

External Reference Information

External Reference

UniProt:F6NJE2

Reference Genes

BioGPS Gene:569226

ENSEMBL:ENSDARG00000025949

KEGG:dre:569226

Monarch:569226

NCBI Gene:569226

UCSC:F6NJE2

Reference Transcript

Other Identifiers

13250530

13280822

13284672

569226

A_15_P188806

A_15_P219946

A_15_P519417

CJ002523

CJ014470

CUST_9493_PI428451953

CUST_9494_PI428451953

CUST_9495_PI428451953

DRER15753

DRER37061

DRER37860

ENSDART00000035931

ENSDART00000035931_1

ENSDART00000035931_2

ENSDART00000101527

GO:0003824

GO:0004672

GO:0005515

GO:0005524

GO:0006468

GO:0007165

GO:0016740

GO:0140096

GT_Xhyb_XM_005166703.1_137956

GT_Xhyb_XM_692596.6_72741

JP002712

XM_681279

XM_692596

Participates

as a component of

p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Danio rerio)

Other forms of this molecule

phospho-K63polyUb-hp-IRAK1 [endosome membrane]

phospho-p-S,T-IRAK1 [cytosol]

phospho-K63polyUb-hp-IRAK1 [cytosol]

phospho-p-IRAK2 [endosome membrane]

phospho-p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]

phospho-p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]

phospho-p-IRAK2 [plasma membrane]

phospho-p-2S,S376,T,T209,T387-IRAK1 [cytosol]

Inferred From

p-IRAK2 [cytosol] (Homo sapiens)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

XP_068079198.1, XP_005166760.1

ENSEMBL

ENSDARP00000118154, ENSDARG00000025949, ENSDART00000137975

ZFIN

ZDB-GENE-071116-5

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