Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Keap1 [cytosol]
Stable Identifier
R-DME-976038
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
KEAP1, Q7KSF5
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular response to chemical stress (Drosophila melanogaster)
KEAP1-NFE2L2 pathway (Drosophila melanogaster)
CUL3:RBX1 ubiquitinates KEAP1 (Drosophila melanogaster)
SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Drosophila melanogaster)
p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Drosophila melanogaster)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Drosophila melanogaster)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Drosophila melanogaster)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Drosophila melanogaster)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Drosophila melanogaster)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Drosophila melanogaster)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Drosophila melanogaster)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Drosophila melanogaster)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
SESN1,SESN1 bind SQSTM1 and KEAP1 (Drosophila melanogaster)
SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Drosophila melanogaster)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Drosophila melanogaster)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Drosophila melanogaster)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Drosophila melanogaster)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Drosophila melanogaster)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Class I MHC mediated antigen processing & presentation (Drosophila melanogaster)
Antigen processing: Ubiquitination & Proteasome degradation (Drosophila melanogaster)
Interaction of E3 with substrate and E2-Ub complex (Drosophila melanogaster)
Ag-substrate:E3:E2:Ub [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
BTB proteins [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
BTB proteins [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
Polyubiquitination of substrate (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
BTB proteins [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
E3:K48-polyubiquitinated substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
BTB proteins [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
E3:Ub:substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
BTB proteins [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
Release of E3 from polyubiquitinated substrate (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
BTB proteins [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
E3:K48-polyubiquitinated substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
BTB proteins [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
Transfer of Ub from E2 to substrate and release of E2 (Drosophila melanogaster)
Ag-substrate:E3:E2:Ub [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
BTB proteins [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
BTB proteins [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
E3:Ub:substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
BTB proteins [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Deubiquitination (Drosophila melanogaster)
Ub-specific processing proteases (Drosophila melanogaster)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Drosophila melanogaster)
USP15:SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Drosophila melanogaster)
SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
Neddylation (Drosophila melanogaster)
AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Drosophila melanogaster)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
BTB proteins [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
NEDD8-CUL3:RBX1:BTB [cytosol] (Drosophila melanogaster)
BTB proteins [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Drosophila melanogaster)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Drosophila melanogaster)
CRL E3 ubiquitin ligases [cytosol] (Drosophila melanogaster)
RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
BTB proteins [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
CRL E3 ubiquitin ligases [cytosol] (Drosophila melanogaster)
RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
BTB proteins [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Drosophila melanogaster)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
BTB proteins [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
NEDD8-CUL3:RBX1:BTB [cytosol] (Drosophila melanogaster)
BTB proteins [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Drosophila melanogaster)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Drosophila melanogaster)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Drosophila melanogaster)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Drosophila melanogaster)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Drosophila melanogaster)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
BTB proteins [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
BTB proteins [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Drosophila melanogaster)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Drosophila melanogaster)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Drosophila melanogaster)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Drosophila melanogaster)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
Keap1 [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q7KSF5
Gene Names
Keap1
Reference Genes
BioGPS Gene:42062 Keap1
ENSEMBL:FBgn0038475
FlyBase:FBgn0038475
Monarch:42062 Keap1
NCBI Gene:42062 Keap1
UCSC:Q7KSF5 Keap1
Reference Transcript
RefSeq:NM_169744.3 Keap1
Other Identifiers
152189_at
1633773_s_at
42062
GO:0003779
GO:0005515
GO:0005634
GO:0005703
GO:0005737
GO:0006979
GO:0008092
GO:0030163
GO:0031463
GO:0043161
GO:0060090
GO:0061709
GO:1990756
Participates
as a member of
SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Drosophila melanogaster)
BTB proteins [cytosol] (Drosophila melanogaster)
as a component of
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
Other forms of this molecule
Keap1 [cytosol]
Keap1 [cytosol]
Inferred From
KEAP1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_732202.2
FlyBase
FBgn0038475
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text