Reactome | Dcp-1 [cytosol]

Dcp-1 [cytosol]

Stable Identifier

R-DME-75975-2

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

CASP8(217-374), O02002

Locations in the PathwayBrowser

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Immune System (Drosophila melanogaster)

- Cytokine Signaling in Immune system (Drosophila melanogaster)
  - Signaling by Interleukins (Drosophila melanogaster)
    - Interleukin-1 family signaling (Drosophila melanogaster)
      - Interleukin-1 signaling (Drosophila melanogaster)
        
        TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
        
        Regulation of NF-kappa B signaling (Drosophila melanogaster)
        
        CASP8 cleaves N4BP1 at D424, D490 (Drosophila melanogaster)
        
        active caspase-8 [cytosol] (Drosophila melanogaster)
        
        Caspase-8 dimer [cytosol] (Drosophila melanogaster)
        
        Homologues of CASP8(217-374) [cytosol] (Drosophila melanogaster)
        
        Dcp-1 [cytosol] (Drosophila melanogaster)
        
        N4BP1 binds IKBKG (Drosophila melanogaster)
        
        active caspase-8 [cytosol] (Drosophila melanogaster)
        
        Caspase-8 dimer [cytosol] (Drosophila melanogaster)
        
        Homologues of CASP8(217-374) [cytosol] (Drosophila melanogaster)
        
        Dcp-1 [cytosol] (Drosophila melanogaster)
- Innate Immune System (Drosophila melanogaster)
  - Toll-like Receptor Cascades (Drosophila melanogaster)
    - Toll Like Receptor 10 (TLR10) Cascade (Drosophila melanogaster)
      - MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
        
        TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
        
        Regulation of NF-kappa B signaling (Drosophila melanogaster)
        
        CASP8 cleaves N4BP1 at D424, D490 (Drosophila melanogaster)
        
        active caspase-8 [cytosol] (Drosophila melanogaster)
        
        Caspase-8 dimer [cytosol] (Drosophila melanogaster)
        
        Homologues of CASP8(217-374) [cytosol] (Drosophila melanogaster)
        
        Dcp-1 [cytosol] (Drosophila melanogaster)
        
        N4BP1 binds IKBKG (Drosophila melanogaster)
        
        active caspase-8 [cytosol] (Drosophila melanogaster)
        
        Caspase-8 dimer [cytosol] (Drosophila melanogaster)
        
        Homologues of CASP8(217-374) [cytosol] (Drosophila melanogaster)
        
        Dcp-1 [cytosol] (Drosophila melanogaster)
    - Toll Like Receptor 2 (TLR2) Cascade (Drosophila melanogaster)
      - Toll Like Receptor TLR1:TLR2 Cascade (Drosophila melanogaster)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
        
        TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
        
        Regulation of NF-kappa B signaling (Drosophila melanogaster)
        
        CASP8 cleaves N4BP1 at D424, D490 (Drosophila melanogaster)
        
        active caspase-8 [cytosol] (Drosophila melanogaster)
        
        Caspase-8 dimer [cytosol] (Drosophila melanogaster)
        
        Homologues of CASP8(217-374) [cytosol] (Drosophila melanogaster)
        
        Dcp-1 [cytosol] (Drosophila melanogaster)
        
        N4BP1 binds IKBKG (Drosophila melanogaster)
        
        active caspase-8 [cytosol] (Drosophila melanogaster)
        
        Caspase-8 dimer [cytosol] (Drosophila melanogaster)
        
        Homologues of CASP8(217-374) [cytosol] (Drosophila melanogaster)
        
        Dcp-1 [cytosol] (Drosophila melanogaster)
      - Toll Like Receptor TLR6:TLR2 Cascade (Drosophila melanogaster)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
        
        TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
        
        Regulation of NF-kappa B signaling (Drosophila melanogaster)
        
        CASP8 cleaves N4BP1 at D424, D490 (Drosophila melanogaster)
        
        active caspase-8 [cytosol] (Drosophila melanogaster)
        
        Caspase-8 dimer [cytosol] (Drosophila melanogaster)
        
        Homologues of CASP8(217-374) [cytosol] (Drosophila melanogaster)
        
        Dcp-1 [cytosol] (Drosophila melanogaster)
        
        N4BP1 binds IKBKG (Drosophila melanogaster)
        
        active caspase-8 [cytosol] (Drosophila melanogaster)
        
        Caspase-8 dimer [cytosol] (Drosophila melanogaster)
        
        Homologues of CASP8(217-374) [cytosol] (Drosophila melanogaster)
        
        Dcp-1 [cytosol] (Drosophila melanogaster)
    - Toll Like Receptor 3 (TLR3) Cascade (Drosophila melanogaster)
      - TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
        
        Regulation of NF-kappa B signaling (Drosophila melanogaster)
        
        CASP8 cleaves N4BP1 at D424, D490 (Drosophila melanogaster)
        
        active caspase-8 [cytosol] (Drosophila melanogaster)
        
        Caspase-8 dimer [cytosol] (Drosophila melanogaster)
        
        Homologues of CASP8(217-374) [cytosol] (Drosophila melanogaster)
        
        Dcp-1 [cytosol] (Drosophila melanogaster)
        
        N4BP1 binds IKBKG (Drosophila melanogaster)
        
        active caspase-8 [cytosol] (Drosophila melanogaster)
        
        Caspase-8 dimer [cytosol] (Drosophila melanogaster)
        
        Homologues of CASP8(217-374) [cytosol] (Drosophila melanogaster)
        
        Dcp-1 [cytosol] (Drosophila melanogaster)
    - Toll Like Receptor 4 (TLR4) Cascade (Drosophila melanogaster)
      - MyD88-independent TLR4 cascade (Drosophila melanogaster)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Drosophila melanogaster)
        
        TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
        
        Regulation of NF-kappa B signaling (Drosophila melanogaster)
        
        CASP8 cleaves N4BP1 at D424, D490 (Drosophila melanogaster)
        
        active caspase-8 [cytosol] (Drosophila melanogaster)
        
        Caspase-8 dimer [cytosol] (Drosophila melanogaster)
        
        Homologues of CASP8(217-374) [cytosol] (Drosophila melanogaster)
        
        Dcp-1 [cytosol] (Drosophila melanogaster)
        
        N4BP1 binds IKBKG (Drosophila melanogaster)
        
        active caspase-8 [cytosol] (Drosophila melanogaster)
        
        Caspase-8 dimer [cytosol] (Drosophila melanogaster)
        
        Homologues of CASP8(217-374) [cytosol] (Drosophila melanogaster)
        
        Dcp-1 [cytosol] (Drosophila melanogaster)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Drosophila melanogaster)
        
        TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
        
        Regulation of NF-kappa B signaling (Drosophila melanogaster)
        
        CASP8 cleaves N4BP1 at D424, D490 (Drosophila melanogaster)
        
        active caspase-8 [cytosol] (Drosophila melanogaster)
        
        Caspase-8 dimer [cytosol] (Drosophila melanogaster)
        
        Homologues of CASP8(217-374) [cytosol] (Drosophila melanogaster)
        
        Dcp-1 [cytosol] (Drosophila melanogaster)
        
        N4BP1 binds IKBKG (Drosophila melanogaster)
        
        active caspase-8 [cytosol] (Drosophila melanogaster)
        
        Caspase-8 dimer [cytosol] (Drosophila melanogaster)
        
        Homologues of CASP8(217-374) [cytosol] (Drosophila melanogaster)
        
        Dcp-1 [cytosol] (Drosophila melanogaster)
    - Toll Like Receptor 5 (TLR5) Cascade (Drosophila melanogaster)
      - MyD88 cascade initiated on plasma membrane (Drosophila melanogaster)
        
        TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
        
        Regulation of NF-kappa B signaling (Drosophila melanogaster)
        
        CASP8 cleaves N4BP1 at D424, D490 (Drosophila melanogaster)
        
        active caspase-8 [cytosol] (Drosophila melanogaster)
        
        Caspase-8 dimer [cytosol] (Drosophila melanogaster)
        
        Homologues of CASP8(217-374) [cytosol] (Drosophila melanogaster)
        
        Dcp-1 [cytosol] (Drosophila melanogaster)
        
        N4BP1 binds IKBKG (Drosophila melanogaster)
        
        active caspase-8 [cytosol] (Drosophila melanogaster)
        
        Caspase-8 dimer [cytosol] (Drosophila melanogaster)
        
        Homologues of CASP8(217-374) [cytosol] (Drosophila melanogaster)
        
        Dcp-1 [cytosol] (Drosophila melanogaster)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Drosophila melanogaster)
      - MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
        
        TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
        
        Regulation of NF-kappa B signaling (Drosophila melanogaster)
        
        CASP8 cleaves N4BP1 at D424, D490 (Drosophila melanogaster)
        
        active caspase-8 [cytosol] (Drosophila melanogaster)
        
        Caspase-8 dimer [cytosol] (Drosophila melanogaster)
        
        Homologues of CASP8(217-374) [cytosol] (Drosophila melanogaster)
        
        Dcp-1 [cytosol] (Drosophila melanogaster)
        
        N4BP1 binds IKBKG (Drosophila melanogaster)
        
        active caspase-8 [cytosol] (Drosophila melanogaster)
        
        Caspase-8 dimer [cytosol] (Drosophila melanogaster)
        
        Homologues of CASP8(217-374) [cytosol] (Drosophila melanogaster)
        
        Dcp-1 [cytosol] (Drosophila melanogaster)
    - Toll Like Receptor 9 (TLR9) Cascade (Drosophila melanogaster)
      - MyD88 dependent cascade initiated on endosome (Drosophila melanogaster)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
        
        TAK1-dependent IKK and NF-kappa-B activation (Drosophila melanogaster)
        
        Regulation of NF-kappa B signaling (Drosophila melanogaster)
        
        CASP8 cleaves N4BP1 at D424, D490 (Drosophila melanogaster)
        
        active caspase-8 [cytosol] (Drosophila melanogaster)
        
        Caspase-8 dimer [cytosol] (Drosophila melanogaster)
        
        Homologues of CASP8(217-374) [cytosol] (Drosophila melanogaster)
        
        Dcp-1 [cytosol] (Drosophila melanogaster)
        
        N4BP1 binds IKBKG (Drosophila melanogaster)
        
        active caspase-8 [cytosol] (Drosophila melanogaster)
        
        Caspase-8 dimer [cytosol] (Drosophila melanogaster)
        
        Homologues of CASP8(217-374) [cytosol] (Drosophila melanogaster)
        
        Dcp-1 [cytosol] (Drosophila melanogaster)

Programmed Cell Death (Drosophila melanogaster)

- Apoptosis (Drosophila melanogaster)
  - Apoptotic execution phase (Drosophila melanogaster)
    - Translocation of active caspase-8 to the mitochondrial membrane (Drosophila melanogaster)
      - active caspase-8 [cytosol] (Drosophila melanogaster)
        
        Caspase-8 dimer [cytosol] (Drosophila melanogaster)
        
        Homologues of CASP8(217-374) [cytosol] (Drosophila melanogaster)
        
        Dcp-1 [cytosol] (Drosophila melanogaster)
  - Caspase activation via extrinsic apoptotic signalling pathway (Drosophila melanogaster)
    - Caspase activation via Death Receptors in the presence of ligand (Drosophila melanogaster)
      - Regulation by c-FLIP (Drosophila melanogaster)
        
        Caspase-8 and FLIP(L) processing at DISC (Drosophila melanogaster)
        
        Caspase-8 dimer [cytosol] (Drosophila melanogaster)
        
        Homologues of CASP8(217-374) [cytosol] (Drosophila melanogaster)
        
        Dcp-1 [cytosol] (Drosophila melanogaster)
        
        active caspase-8 [cytosol] (Drosophila melanogaster)
        
        Caspase-8 dimer [cytosol] (Drosophila melanogaster)
        
        Homologues of CASP8(217-374) [cytosol] (Drosophila melanogaster)
        
        Dcp-1 [cytosol] (Drosophila melanogaster)
- Regulated Necrosis (Drosophila melanogaster)
  - RIPK1-mediated regulated necrosis (Drosophila melanogaster)
    - Regulation of necroptotic cell death (Drosophila melanogaster)
      - RIPK1 is cleaved by CASP8 (Drosophila melanogaster)
        
        Caspase-8 dimer [cytosol] (Drosophila melanogaster)
        
        Homologues of CASP8(217-374) [cytosol] (Drosophila melanogaster)
        
        Dcp-1 [cytosol] (Drosophila melanogaster)
        
        active caspase-8 [cytosol] (Drosophila melanogaster)
        
        Caspase-8 dimer [cytosol] (Drosophila melanogaster)
        
        Homologues of CASP8(217-374) [cytosol] (Drosophila melanogaster)
        
        Dcp-1 [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:O02002

Gene Names

Dcp-1

Reference Genes

BioGPS Gene:37729 Dcp-1

CTD Gene:37729 Dcp-1

ENSEMBL:FBgn0010501

FlyBase:FBgn0010501

KEGG:dme:Dmel_CG5370 Dcp-1

Monarch:37729 Dcp-1

NCBI Gene:37729 Dcp-1

UCSC:O02002 Dcp-1

Reference Transcript

RefSeq:NM_057626.4 Dcp-1

Other Identifiers

153796_at

1637487_at

37729

GO:0004197

GO:0005515

GO:0005737

GO:0005739

GO:0005759

GO:0005829

GO:0006508

GO:0006915

GO:0007300

GO:0008233

GO:0008234

GO:0009267

GO:0010508

GO:0010623

GO:0012501

GO:0016239

GO:0016322

GO:0016787

GO:0022414

GO:0043025

GO:0043525

GO:0045476

GO:0045751

GO:0048477

GO:0048856

GO:0071598

GO:0097194

GO:0097200

GO:1900074

GO:1990525

Participates

as a member of

Homologues of CASP8(217-374) [cytosol] (Drosophila melanogaster)

Other forms of this molecule

Dcp-1 [cytosol]

Dcp-1 [nucleoplasm]

Dcp-1 [cytosol]

Dcp-1 [nucleoplasm]

Dcp-1 [cytosol]

Dcp-1 [mitochondrial outer membrane]

Dcp-1 [cytosol]

Inferred From

CASP8(217-374) [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_476974.1

ENSEMBL

FBpp0071971, FBtr0072062, FBgn0010501

FlyBase

FBgn0010501

PRO

O02002

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q24306 Diap1	7	BIRC3 [cytosol] (R-DME-50845) XIAP [cytosol] (R-DME-50849) K48pUb-XIAP [cytosol] (R-DME-5675477) K48pUb-BIRC3 [cytosol] (R-DME-5675478) XIAP [nucleoplasm] (R-DME-3322366) TH [cytosol] (R-DME-390182) Phospho TH [cytosol] (R-DME-390103)	0.534	2

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