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Fadd [cytosol]
Stable Identifier
R-DME-54639
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
FADD, Q9V3B4
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Drosophila melanogaster)
Apoptosis (Drosophila melanogaster)
Caspase activation via extrinsic apoptotic signalling pathway (Drosophila melanogaster)
Caspase activation via Death Receptors in the presence of ligand (Drosophila melanogaster)
Dimerization of procaspase-8 (Drosophila melanogaster)
TNF-mediated dimerization of procaspase-8 (Drosophila melanogaster)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Drosophila melanogaster)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Drosophila melanogaster)
Fadd [cytosol] (Drosophila melanogaster)
TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] (Drosophila melanogaster)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Drosophila melanogaster)
Fadd [cytosol] (Drosophila melanogaster)
Regulation by c-FLIP (Drosophila melanogaster)
Caspase-8 and FLIP(L) processing at DISC (Drosophila melanogaster)
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Drosophila melanogaster)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Drosophila melanogaster)
Fadd [cytosol] (Drosophila melanogaster)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Drosophila melanogaster)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Drosophila melanogaster)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Drosophila melanogaster)
Fadd [cytosol] (Drosophila melanogaster)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Drosophila melanogaster)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Drosophila melanogaster)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Drosophila melanogaster)
Fadd [cytosol] (Drosophila melanogaster)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Drosophila melanogaster)
Fadd [cytosol] (Drosophila melanogaster)
Regulated Necrosis (Drosophila melanogaster)
RIPK1-mediated regulated necrosis (Drosophila melanogaster)
Regulation of necroptotic cell death (Drosophila melanogaster)
CASP8 activity is inhibited (Drosophila melanogaster)
FLIP(L) and procaspase-8 form heterodimer (Drosophila melanogaster)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Drosophila melanogaster)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Drosophila melanogaster)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Drosophila melanogaster)
Fadd [cytosol] (Drosophila melanogaster)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Drosophila melanogaster)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Drosophila melanogaster)
Fadd [cytosol] (Drosophila melanogaster)
FLIP(S) and procaspase-8 form heterodimer (Drosophila melanogaster)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Drosophila melanogaster)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Drosophila melanogaster)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Drosophila melanogaster)
Fadd [cytosol] (Drosophila melanogaster)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Drosophila melanogaster)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Drosophila melanogaster)
Fadd [cytosol] (Drosophila melanogaster)
RIPK1 is cleaved by CASP8 (Drosophila melanogaster)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Drosophila melanogaster)
Fadd [cytosol] (Drosophila melanogaster)
TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Drosophila melanogaster)
Fadd [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Death Receptor Signaling (Drosophila melanogaster)
TNF signaling (Drosophila melanogaster)
Regulation of TNFR1 signaling (Drosophila melanogaster)
Caspase-8 and FLIP(L) processing at TNFR signaling complex (Drosophila melanogaster)
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Drosophila melanogaster)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Drosophila melanogaster)
Fadd [cytosol] (Drosophila melanogaster)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Drosophila melanogaster)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Drosophila melanogaster)
Fadd [cytosol] (Drosophila melanogaster)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Drosophila melanogaster)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Drosophila melanogaster)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Drosophila melanogaster)
Fadd [cytosol] (Drosophila melanogaster)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Drosophila melanogaster)
Fadd [cytosol] (Drosophila melanogaster)
RIPK1 is cleaved by CASP8 (Drosophila melanogaster)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Drosophila melanogaster)
Fadd [cytosol] (Drosophila melanogaster)
TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Drosophila melanogaster)
Fadd [cytosol] (Drosophila melanogaster)
RIPK1 is cleaved by CASP8:FLIP(L) (Drosophila melanogaster)
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Drosophila melanogaster)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Drosophila melanogaster)
Fadd [cytosol] (Drosophila melanogaster)
TRADD:TRAF2:RIPK1(325-671):FADD:p43/p41CASP8:p43 FLIP(L) [cytosol] (Drosophila melanogaster)
TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Drosophila melanogaster)
Fadd [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9V3B4 Fadd
Gene Names
Fadd, BG4, CG12297
Chain
chain:1-239
Reference Genes
BioGPS Gene:42594 Fadd
KEGG:dme:Dmel_CG12297 Fadd
Monarch:42594 Fadd
NCBI Gene:42594 Fadd
UCSC:Q9V3B4 Fadd
Reference Transcript
RefSeq:NM_142749.3 Fadd
Other Identifiers
150341_at
1630987_at
42594
GO:0002230
GO:0002376
GO:0005123
GO:0005515
GO:0005737
GO:0005829
GO:0006915
GO:0006955
GO:0006963
GO:0007165
GO:0007291
GO:0031265
GO:0045089
GO:0050700
GO:0050829
GO:0061057
GO:0089720
GO:0097191
GO:0098542
Participates
as a component of
TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Drosophila melanogaster)
TRADD:TRAF2:RIPK1:FADD [cytosol] (Drosophila melanogaster)
Other forms of this molecule
BG4 [cytosol]
Inferred From
FADD [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_651006.1
ENSEMBL
FBpp0083574
,
FBtr0084176
,
FBgn0038928
FlyBase
FBgn0038928
PRO
Q9V3B4
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q7K4Z4 imd
1
IMD [cytosol]
(R-DME-206183)
0.502
2
UniProt:Q8IRY7 Dredd
13
DREDD [cytosol]
(R-DME-205876)
Dredd [cytosol]
(R-DME-2976746)
Dredd [cytosol]
(R-DME-2976745)
Dredd [cytosol]
(R-DME-9710073)
Dredd [cytosol]
(R-DME-9710105)
Dredd [cytosol]
(R-DME-9686132)
phospho-Dredd [cytosol]
(R-DME-198636)
phospho-Dredd [cytosol]
(R-DME-9627087)
Dredd [cytosol]
(R-DME-141639)
Dredd [cytosol]
(R-DME-141638)
Dredd [cytosol]
(R-DME-622418)
Dredd [cytosol]
(R-DME-57033)
Dredd [cytosol]
(R-DME-622412)
0.502
2
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